Category Archives: Anesthesiology

PowerPoint on neuromuscular blockers pharmacology: mechanism of action, classification, uses, interactions and more

The following pharmacology lecture was developed by the Department of Pharmacology and Therapeutics, at American University of Beirut.

Download PPT file: Neuromuscular Blockers

An outline of the slideshow content:

  • Neuromuscular blockers differ from each other in: • Mechanism of action • Duration of action • Speed of onset and offset of action • Selectivity of action and safety margin • Adverse effects
  • Classification of Blockers
  • Site of Action
  • Non-depolarizing Block
  • Comparison of Competitive and Depolarizing Blocking Agents
  • Sequence of Paralysis: Fingers, orbit (small muscles) limbs neck Trunk Diaphragm,  Intercostals. Recovery in Reverse
  • Adverse Effects/Toxicity
  • Dual Block by Depolarizing Agents
  • Other Effects of Neuromuscular Blockers
  • Hemodynamic Effects of d-Tubocurarine and Pancuronium CO

Non-depolarizing blocking agents

Atracurium (Tracrium), Cisatracurium (Nimbex), Doxacurium (Nuromax), Gallamine (Flaxedil), Mivacurium (Mivacron), Pancuronium (Pavulon), Pipecuronium, Rapacuronium (Raplon)

Depolarizing blocking agents

Succinylcholine, Decamethonium

The largest case of scientific misconduct to date ?

Found via Pharmola: “Scott S. Reuben, MD, of Baystate Medical Center in Springfield, Mass., a pioneer in the area of multimodal analgesia, is said to have fabricated his results in at least 21, and perhaps many more, articles dating back to 1996. The confirmed articles were published in Anesthesiology, Anesthesia and Analgesia, the Journal of…

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