Category Archives: Antiretrovirals

Animation: NRTIs mechanism of action

Animation: NRTIs mechanism of action

Nucleoside analog reverse transcriptase inhibitors (NRTIs) are nucleoside analogues that act as competitive inhibitors of HIV-1 reverse transcriptase. As shown in the animation, these drugs compete with nucleoside triphosphates for access to reverse transcriptase. All NRTIs lack a 3-hydroxyl group; thus, their incorporation into a growing DNA chain results in its termination. They require intracytoplasmicContinue Reading

Etravirine (Intelence) for HIV infection: not recommended by the Scottish Medicines Consortium

This is an excerpt from the Scottish Medicines Consortium (SMC) advice on etravirine (Intelence). ADVICE: following a full submission etravirine  (Intelence),  in  combination  with  a  boosted  protease  inhibitor and  other antiretroviral medicinal  products,  is not  recommended  for use within NHS Scotland  for  the treatment  of  human  immunodeficiency  virus  type  1  (HIV-1)  infection  in  antiretroviral treatment-experiencedContinue Reading

Antiretrovirals drugs: video review for nurses (NCLEX)

This video review covers the medications used for the treatment of HIV infection. The target audience of the review is nursing students and nurses, it covers mainly adverse effects of the different drug classes. More on nursing pharmacology Technorati : HIV, NCLEX, NRTIs,  NNRTI, Nurses & nursing studentsContinue Reading

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