Pharmacokinetics in critical care: PowerPoint presentation

This presentation entitled “Applied Pharmacokinetics in the Adult Critically Ill” is oriented to show pharmacokinetics concepts that are relevant to the ICU. Some of them are: First pass metabolism Patients in whom oral administration should be avoided P-glycoprotein (P-gp) Relevance of drug distribution in compartments Context specific half life Cytochrome 450 Pharmacogenetics Pharmacotherapy in critical […]

Xigris (Drotrecogin alfa activated): concerns of serious bleeding and increased death trigger FDA safety review

On February 4th, 2009 the FDA announced an ongoing safety review of Xigris (Drotrecogin alfa [activated]). An introduction from Wikipedia: Drotrecogin alfa (activated) (Xigris, marketed by Eli Lilly and Company) is a recombinant form of human activated protein C ( rhAPC) that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties. Drotrecogin alpha (activated) belongs to the class […]

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