Category Archives: Pharmacokinetics

Pharmacokinetics. Compartment(s) definition

The following pharmacology definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Compartment(s): The space or spaces in the body, which a drug appears to occupy after it has been absorbed. Pharmacokinetic compartments are mathematical constructs and need not correspond to the fluid volumes of the…Continue Reading

Pharmacokinetics. First order kinetics definition and animation.

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. First Order Kinetics: According to the law of mass action, the velocity of a chemical reaction is proportional to the product of the active masses (concentrations) of the reactants.Continue Reading

Pharmacokinetics. A definition of clearance (renal and non renal)

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Clearance: The clearance of a chemical is the volume of body fluid from which the chemical is, apparently, completely removed by biotransformation and/or excretion, per unit time. In fact, the chemical is only partially…Continue Reading

Pharmacokinetics topics. What is a generic drug?

This generic drugs definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine . Generic Drugs: Drug formulations of identical composition with respect to the active ingredient, i.e., drugs that meet current official standards of identity, purity, and quality of active ingredient. Drug dosage forms considered as…Continue Reading

Alpha 1 adrenergic receptors antagonists (blockers): mechanism of action animation

Additional information about alpha 1 blocking drugs.  Source: Bertram G. Katzung, Basic & Clinical Pharmacology (Mc Graw-Hill Medical, 2007) ” Phentolamine, an imidazoline derivative, is a potent competitive antagonist at both alpha 1 and alpha 2 receptors . Phentolamine causes a reduction in peripheral resistance through blockade of alpha 1 receptors and possibly alpha 2…Continue Reading

Pharmacokinetics. What is clearance -volume/unit time- (Cl, Clx)?

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Cl, Clx: Clearance – in volume/unit time – of a drug or chemical from a body fluid, usually plasma or blood, by specified route(s) and mechanism(s) of elimination, as indicated by a subscript, e.g.,…

Pharmacokinetics. What is biotranslocation?

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine . Biotranslocation: The movement of chemicals (drugs) into, through, and out of biological organisms or their parts. In studying biotranslocation one is concerned with the identification and description of such movement, elucidation of the…

Pharmacokinetics. What is biotransformation?

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine . Biotransformation: Chemical alteration of an agent (drug) that occurs by virtue of the sojourn of the agent in a biological system. Spontaneous decay of radium would not be considered a biotransformation even if…Continue Reading

Pharmacodynamics and pharmacokinetics. What is biopharmaceutics?

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine . Biopharmaceutics: The science and study of the ways in which the pharmaceutical formulation of administered agents can influence their pharmacodynamic and pharmacokinetic behavior. Differences in pharmaceutical properties can cause substantial differences in the…

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