Category Archives: Nurses & nursing students

FDA video: interaction of IV ceftriaxone with calcium-containing products

intravenous The FDA updated the full prescribing information of ceftriaxone (Rocephin and generics). This is an update to a previous ( september 2007) alert on the risk of interaction between ceftriaxone and calcium-containing IV products, the 2007 alert was based on reported fatal cases in neonates.

In addition to the alert, the FDA requested the manufacturer (Roche) to conduct in vitro studies to assess the potential of precipitation of ceftriaxone and calcium  when ceftriaxone and calcium-containing products are mixed in vials and infusion lines.

The updated recommendations include the following:
Concomitant use of ceftriaxone and intravenous calcium-containing products is contraindicated in neonates (<28 days of age). Ceftriaxone should not be used in neonates (<28 days of age) if they are receiving (or are expected to receive) calcium-containing intravenous products.

In patients >28 days of age, ceftriaxone and calcium-containing products may be administered sequentially, provided the infusion lines are thoroughly flushed between infusions with a compatible fluid.

Ceftriaxone must not be administered simultaneously with intravenous calcium-containing solutions via a Y-site in any age group.

FDA now recommends that ceftriaxone and calcium-containing products may be used concomitantly in patients >28 days of age, using the precautionary steps above because the risk of precipitation is low in this population.

FDA had previously recommended, but no longer recommends, that in all age groups ceftriaxone and calcium-containing products should not be administered within 48 hours of one another.

In addition, the agency repeats three of the 2007 recommendations:

Do not reconstitute or mix ceftriaxone with a calcium-containing product, such as Ringer’s or Hartmann’s solution or parenteral nutrition containing calcium, because particulate formation can result.

There are no data on interactions between intravenous ceftriaxone and oral calcium-containing products or between intramuscular ceftriaxone and intravenous or oral calcium-containing products.

Report patients who have adverse events following ceftriaxone administration to the FDA’s MedWatch program.

 

Antitubercular and antiviral (HSV, CMV, influenza) drugs: NCLEX video review

This video is targeted to nurses and nursing students, as a pharmacology review previous to the NCLEX exam. It reviews the following drug classes: Antimycobacterial (antitubercular) drugs: isoniazid, pyrazinamide, rifampin, ethambutol Drugs for the treatment of herpesvirus infections: acyclovir famciclovir Drugs for the treatment of influenza:amantadine, rimantadine, zanamivir, oseltamivir Drugs for the treatment of citomegalovirus…

Gastrointestinal drugs for nurses

Below is a very good review presentation from NurseReview.org about drugs that affect the gastrointestinal system: 1. Drugs affecting GI secretions 2. Laxatives 3. Anti-diarrheals 4. Emetics and anti-emetics More on nursing pharmacology Technorati : Anti-diarrheals, Anti-emetics, Laxatives, NCLEX, Nurses &amp; nursing students, PPI, pharmacology for nurses

NCLEX pharmacology video review: antibiotics

This video pharmacology review for nurses deals with antibiotics: penicilins, cephalosporins, aminoglycosides, vancomycin and others. Part 2 covers: macrolides, tetracyclines, chloramphenicol, quinolones, and sulfonamides. There is a related animation that explains  linezolid mechanism. More on nursing pharmacology Further reading Gilbert, D; Moellering R (editors) “Sanford Guide to Antimicrobial Therapy”, 39th edition. Antimicrobial therapy: 2009 Hauser,…

Respiratory drugs for nurses: antihistamines, bronchodilators, antitussives and others

This PowerPoint presentation developed by NurseReview.org summarizes core concepts of the drugs used for treatment of respiratory conditions. Antihistamines Antitussives Decongestants Drugs for COPD: Bronchodilators, inhaled steroids, Leukotriene receptor blockers Expectorants Great pharmacology slides for nurses and nursing students preparing for NCLEX-RN. More on nursing pharmacology

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