Category Archives: Psychiatry

EMEA reviewed methylphenidate (Ritalin) for ADHD and issued recommendations for its safer use

EMEA’s Committee for Medicinal Products for Human Use (CHMP) has reviewed methylphenidate for attention deficit/hyperactivity disorder (ADHD). Quoting the press release issued 22 January 2009: The European Medicines Agency (EMEA) has concluded that methylphenidate-containing medicines remain suitable for the treatment of children aged six years or older and adolescents with attention deficit/hyperactivity disorder (ADHD). It hasContinue Reading

Cochrane podcast. Nicotine receptors partial agonists: varenicline (Champix, Chantix)

The Cochrane Collaboration issued a podcast reviewing varenicline (Champix, Chantix) and bupropion. They review clinical trials, safety concerns among other relevant aspects. Nicotine receptor partial agonists for smoking cessation Read a related post defining partial agonists.Continue Reading

Atypical antipsychotics and sudden cardiac death: medical media coverage

This is a compilation of the media impact of the recent paper published in the NEJM: Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac Death. Atypical antipsychotics (Second generation antipsychotics) include: Clozapine (Clozaril),Olanzapine (Zyprexa),Risperidone (Risperdal), Quetiapine (Seroquel), Ziprasidone (Geodon), Amisulpride (Solian), Paliperidone (Invega) Physician’s First Watch Antipsychotics Increase Risks for Sudden Cardiac DeathContinue Reading

Antipsychotics would increase mortality in patients with Alzheimer’s disease

Via Physician’s First Watch: Patients with Alzheimer Disease on Antipsychotics Show Increased Mortality Patients with Alzheimer disease who take antipsychotic drugs may be at increased long-term risk for death, according to a study published online in Lancet Neurology.Continue Reading

Sertraline (Zoloft and associated names): review by the CHMP

The CHMP has issued a question and answer document dated 18 December 2008, about the review of sertraline (Zoloft and associated names) Questions and answers on the referral for Zoloft – Sertraline Hard capsules and Film coated tablets – 25 mg, 50 mg, and 100 mg Concentrate for oral solution – 20 mg/ml The EuropeanContinue Reading

Aripiprazole IM (Abilify) for agitation control in patients with schizophrenia: SMC review

The Scottish Medicines Consortium issued on 7th December, 2008 an advice on the aripiprazole intramuscular injection (Abilify): Aripiprazole intramuscular injection (Abilify ) is accepted for use in NHS Scotland for the rapid control of agitation and disturbed behaviours in patients with schizophrenia when oral therapy is not appropriate.Continue Reading

Varenicline (Champix) psychiatric adverse effects: recommendations to patients from Health Canada

Health Canada has issued  an information update about varenicline (Champix), giving some recommendations to patients: Information Update 2009-01 January 6, 2009 For immediate release OTTAWA – Health Canada is reminding Canadians who are taking, or considering taking, the smoking-cessation aid Champix of important safety information for this product. Health Canada is also informing Canadians thatContinue Reading

Serotonin syndrome

Serotonin syndrome is a predictable clinical feature that involves excess serotonergic agonism of central nervous system (CNS) receptors and peripheral serotonergic receptors. The following PowerPoint was published on Stanford School of Medicine’s Scalpel: Serotoninn syndrome features Download: Serotonin syndrome PPT file MedExcel posted recently a mnemonic to remember the clinical components of serotonin syndrome Causes HARM:Continue Reading

Lithium side effects mnemonic

Lithium: side effects LITH: Leukocytosis Insipidus [diabetes insipidus, tied to polyuria] Tremor/ Teratogenesis Hypothyroidism Thanks to MedExcelContinue Reading

Mnemonic to remember which benzodiazepines don’t have hepatic metabolism

Benzodiazepines: ones not metabolized by the liver (safe to use in liver failure) LOT: Lorazepam Oxazepam Temazepam Thanks to MedExcel Remember to check the animation on the mechanism of action of benzodiazepines.Continue Reading

Duloxetine (Cymbalta, Yentreve): a serotonin-norepinephrine reuptake inhibitor for major depression. Australian prescriber review

From Australian Prescriber: Duloxetine Cymbalta (Eli Lilly) 30 mg and 60 mg capsules Approved indication: major depression Australian Medicines Handbook section 18.1.2 Duloxetine is a new antidepressant which selectively inhibits serotonin and noradrenaline reuptake. It also weakly inhibits dopamine uptake. (See details of its mechanism of action)Continue Reading

Quetiapine extended release tablets (Seroquel XR): efficacy, tolerability and adherence.

Information about quetiapine extended release tablets, from the National Prescribing Service RADAR “There is no evidence that extended-release tablets improve efficacy, tolerability or adherence Once-daily dosing with quetiapine extended-release tablets is equivalent to twice-daily dosing with quetiapine immediate-release tablets, e.g. quetiapine extended release 600 mg once daily is equivalent to quetiapine immediate release 300 mgContinue Reading

Paliperidone (Invega) manufacturer withdraws application for its use in bipolar disorder

Reproduction of EMEA’s press release about the Janssen-Cilag International  application withdrawal for an extension of indication for Invega (paliperidone): PRESS RELEASE Janssen-Cilag International N.V. withdraws its application for an extension of indication for Invega (paliperidone) The European Medicines Agency (EMEA) has been formally notified by Janssen-Cilag International N.V. of its decision to withdraw its applicationContinue Reading

Antipsychotics for acute and chronic pain: a systematic review

Summary Analgesic effects of antipsychotics in acute and chronic painful states Antipsychotics are used in different chronic pain states (e.g. chronic headache, fibromyalgia and diabetic neuropathia). With atypical antipsychotics a new class of antipsychotics is available, with lesser extrapyramidal side effects and additional benefits. The review authors assessed the analgesic efficacy and adverse effects ofContinue Reading

Are you a visual learner interested in learning psychopharmacology? Click here to get our videos