Pharmacology Corner » Respiratory http://pharmacologycorner.com Pharmacology CME for physicians, pharmacists and nurses. Mon, 12 Jul 2010 22:36:24 +0000 en hourly 1 http://wordpress.org/?v=3.0 Respiratory drugs table: pharmacology of asthma and COPD http://pharmacologycorner.com/respiratory-drugs-table-pharmacology-of-asthma-and-copd/ http://pharmacologycorner.com/respiratory-drugs-table-pharmacology-of-asthma-and-copd/#comments Wed, 11 Mar 2009 14:42:02 +0000 Flavio Guzmán, MD http://pharmacologycorner.com/respiratory-drugs-table-pharmacology-of-asthma-and-copd/ The Dept. of Pharmacology at University of Utah posted in their website tables to review respiratory pharmacology. This study aid analizes therapeutic uses & specificity, toxicity and side effects of the following drug classes:

  • Bronchodilators: epinephrine, Ephedrine, Isoproterenol, Terbutaline, Isoetharine, Ipratropium bromide, Theophylline, Aminophylline.
  • Leukotriene D4 receptors antagonists:Zafirlukast, Zileutron.
  • Inhibition of mast cell degranulation: Cromolyn sodium, Nedocromil sodium´
  • Corticosteroids: Beclomethasone, Flunisolide, Tramcinolone acetonide, Prednisone

Download: table of agents used for the treatment of asthma and COPD

]]> http://pharmacologycorner.com/respiratory-drugs-table-pharmacology-of-asthma-and-copd/feed/ 1 Cochrane review podcast: Commercial spacers as effective as home-made? http://pharmacologycorner.com/cochrane-review-podcast-commercial-spacers-as-effective-as-home-made/ http://pharmacologycorner.com/cochrane-review-podcast-commercial-spacers-as-effective-as-home-made/#comments Fri, 30 Jan 2009 16:54:26 +0000 Flavio Guzmán, MD http://pharmacologycorner.com/?p=988

Spacers in combination with metered-dose inhalers for delivery of bronchodilator drugs have proved to be effective. However, in some low income areas ( mainly in developing countries) it may not be something affordable or accesible to patients. As a response to this issue, home-made spacers (tipically with plastic bottles) have been widely used.

In this Cochane audio review, Dr. Carlos Rodríguez from Colombia compares the response of beta 2 agonists delivered through metered-dose inhalers attached to comercially available spacers versus home made spacers.

Commercial versus home-made spacers. Cochrane Intervention review.

Plain language summary

Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children

The aim of this review was to compare the response to inhaled beta-2 agonists delivered through a metered-dose inhaler (MDI) attached to home-made spacers, compared with beta-2 agonists delivered through a MDI attached to commercially produced spacers in children with acute exacerbations of wheezing or asthma. Six randomized clinical trials (RCTs) with 658 participants met the inclusion criteria of the review. Overall, this review fails to identify a difference between these two delivery methods for delivering bronchodilator therapy to children with acute asthma or lower airways obstruction attacks. However, given the small total sample and wide confidence intervals, equivalence between the treatments cannot be claimed.

Source: [Intervention Review]Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children

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