Category Archives: Antithrombotics

Heparins PowerPoint presentation

PPT discussing chemistry, mechanism of action, classification,pharmacokinetics and clinical uses of heparin. Continue Reading

Warfarin PowerPoint presentation

PPT on Warfarin pharmacotherapy. Discusses mechanism of action, dosing and target INRs, drug and food interactions, and patient counseling.Continue Reading

The coagulation cascade

Coagulation cascade: several resources (videos, animations and tutorials) depicting coagulation factors and pathways.Continue Reading

COGENT trial: no clopidogrel-PPIs interaction

According to the results of the COGENT trial, the combination of the antiplatelet clopidogrel and the PPI omeprazole does not produce clinically relevant cardiovascular interactions.Continue Reading

Antiplatelet agents: mechanisms of action and general overview

This post is an overview on antiplatelet drugs, we will focus on the classification of agents and  their mechanism of action. The most relevant facts related to therapeutics will also be discussed here,  followed by a video review by  K.G. Paul, M.D. A related article explores the pharmacology of thrombolytic agents. Classification of antiplatelet agentsContinue Reading

Prasugrel (Effient): mechanism of action, indications and adverse effects

Overview on the mechanism of action, indications, adverse effects profile of prasugrel (Efient in the EU, Effient in the USA). PowerPoint on the TIMI TRITON 38 trial.Continue Reading

Animation on coagulation physiology and the mechanism of action of glycoprotein IIb/IIIa antagonists

Animation on coagulation physiology and mechanism of action of Gp IIb/IIIa inhibitors (abciximab, eptifibatide and tirofiban) and other antiplatelet drugs.Continue Reading

Warfarin dosing: the role of genes

Warfarin dosing: the genes VKORC1, CYP2C9, CYP4F2 are determinants in the dosing of warfarin. Role in clinical practice of pharmacogenomics: genetic testing to guide warfarin therapy.Continue Reading

FDA approves ATryn (recombinant human antithrombin) for the treatment of hereditary antithrombin deficiency

The FDA issued a press release (February 6th, 2009) announcing the approval of the first biological product produced by genetically engineered animals: recombinant human antithrombin. Some excerpts from the press release: The U.S. Food and Drug Administration today issued its first approval for a biological product produced by genetically engineered (GE) animals. The approval isContinue Reading

Genetic variants of cytochrome P-450 linked to decreased response to clopidogrel (Plavix,Iscover and others)

From Physician’s First Watch: Genetic Variants Linked to Decreased Response to Clopidogrel, Increased Cardiovascular Risk Polymorphisms in the gene encoding the cytochrome P-450 2C19 enzyme (CYP2C19) not only confer reduced response to clopidogrel, but also are associated with increased risk for cardiovascular events, according to three studies published online by the New England Journal ofContinue Reading

EMEA positive opinion for prasugrel (Efient)

Press release about the positive opinion of the CHMP for the antiplatelet agent Efient (prasugrel): COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE SUMMARY OF POSITIVE OPINION for EFIENT International Nonproprietary Name (INN): prasugrel On 18 December 2008  the Committee for Medicinal Products  for Human Use (CHMP) adopted a positive opinion, recommending to grant a marketingContinue Reading

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