Warfarin PowerPoint presentation

PPT on Warfarin pharmacotherapy. Discusses mechanism of action, dosing and target INRs, drug and food interactions, and patient counseling.

The coagulation cascade

Coagulation cascade: several resources (videos, animations and tutorials) depicting coagulation factors and pathways.

COGENT trial: no clopidogrel-PPIs interaction

According to the results of the COGENT trial, the combination of the antiplatelet clopidogrel and the PPI omeprazole does not produce clinically relevant cardiovascular interactions.

Antiplatelet agents: mechanisms of action and general overview

This post is an overview on antiplatelet drugs, we will focus on the classification of agents and  their mechanism of action. The most relevant facts related to therapeutics will also be discussed here,  followed by a video review by  K.G. Paul, M.D. A related article explores the pharmacology of thrombolytic agents. Classification of antiplatelet agents […]

Warfarin dosing: the role of genes

Warfarin dosing: the genes VKORC1, CYP2C9, CYP4F2 are determinants in the dosing of warfarin. Role in clinical practice of pharmacogenomics: genetic testing to guide warfarin therapy.

Genetic variants of cytochrome P-450 linked to decreased response to clopidogrel (Plavix,Iscover and others)

From Physician’s First Watch: Genetic Variants Linked to Decreased Response to Clopidogrel, Increased Cardiovascular Risk Polymorphisms in the gene encoding the cytochrome P-450 2C19 enzyme (CYP2C19) not only confer reduced response to clopidogrel, but also are associated with increased risk for cardiovascular events, according to three studies published online by the New England Journal of […]

EMEA positive opinion for prasugrel (Efient)

Press release about the positive opinion of the CHMP for the antiplatelet agent Efient (prasugrel): COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE SUMMARY OF POSITIVE OPINION for EFIENT International Nonproprietary Name (INN): prasugrel On 18 December 2008  the Committee for Medicinal Products  for Human Use (CHMP) adopted a positive opinion, recommending to grant a marketing […]

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