Category Archives: Diuretics

PowerPoint presentation on diuretics: MOA, indications, side effects and therapeutic considerations

The following set of lectures has been created by Dr. Edwin Jackson and were published in the Division for Cardiovascular Pharmacology, a branch of the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Part 1: How diuretics work

Download: DIURETICS Part 1 – How they work. PPT file

Part 2: What do diuretics do

Na-K-2Cl SYMPORT INHIBITORS (Loop Diuretics, High Ceiling Diuretics)

Na-Cl SYMPORT INHIBITORS (Thiazide Diuretics, Thiazide-Like Diuretics)

Na CHANNEL INHIBITORS

MINERALOCORTICOID RECEPTOR ANTAGONISTS (K-Sparing Diuretics, Aldosterone Antagonists)

THERAPEUTIC EFFECTS

ADVERSE EFFECTS

OTHER EFFECTS

Download: DIURETICS Part II – What they do. PPT file

Part 3: When Do I Use them?

Download: DIURETICS Part III – When do I use them. Download PPT

Part 4: How do I use them?

Download DIURETICS Part IV – How do I use them (PPT file).

Video animation on renal physiology and diuretics mechanism of action.

Mechanism of action of loop diuretics ( Source: Bertram Katzung, Basic and Clinical Pharmacology, Mc Graw Hill Medical, 2007): Pharmacodynamics These drugs inhibit NKCC2, the luminal Na+/K+/2Cl- transporter in the thick ascending limb of Henle’s loop. By inhibiting this transporter, the loop diureticsContinue Reading

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