Category Archives: Thrombolytics

The coagulation cascade

This article is an approach to the physiology of coagulation. Several resources  (videos, animations and tutorials) are presented to help the reader learn the key coagulation factors and pathways.

Coagulation cascade: extrinsic, intrinsic and common pathways differentiation

Video animation contents:

  • Intrinsic pathway
  • Extrinsic pathway (endothelium exposure to VIIa factor).
  • Common pathway

Extrinsic, intinsic and common pathways

Hemostasis overview

The following animation depicts the process of hemostasis after endothelial damage (vasoconstriction, platelet adhesion, activation, interaction between coagulation factors and thrombin activation).

hemostasis

Hemostasis

Coagulation cascade learning module

This tutorial features interactive exercises and animations that help understand the role of coagulation cascade factors and physiological hemostatic processes.

It highlights clinical disorders on intrinsic and extrinsic pathways, with a special section overviewing Von Willebrand’s disease.

clotting_cascade

Clotting cascade learning module

Coagulation factors commented

This animation focuses exclusively on the coagulation cascade factors and its sequence of activation. It emphasises biochemical and laboratory aspects.

clotting_factors_2

Coagulation factors

Thrombolytic agents: mechanism of action, indications, contraindications and side effects

Thrombolytic agents are used to lyse already formed blood clots in clinical settings where ischemia may be fatal ( acute mycardial infarction, pulmonary embolism, ischemic stroke, and arterial thrombosis). Very precise indications rule the use of these drugs, which are not free from serious side effects ( bleeding). Outline: Mechanism of action of thrombolytic therapy…

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