Category Archives: Videos

Video on aspirin pharmacokinetics: the role of the ion trapping phenomenon

Some key facts before you watch the video on aspirin absorption:

  • Aspirin is a weak acid (pKa 3.4).
  • Acidic drugs in an acidic environment (like gastric lumen) are most likely to be in their neutral form ( non-ionized )
  • Non-ionized drugs are more lipid soluble. Hence, they can be readily absorbed
  • Since aspirin is a weak acid and gastric pH is an acidic environment,  it can be readily absorbed.
  • Bloodstream has a pH of around 7.4, therefore aspirin tends to be ionized. This prevents the drug from diffusing back to the stomach.

Source: University of Rhode Island Pharmacy Animations

Now, watch again the video paying attention to the following details.

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Antiplatelet agents: mechanisms of action and general overview

This post is an overview on antiplatelet drugs, we will focus on the classification of agents and  their mechanism of action. The most relevant facts related to therapeutics will also be discussed here,  followed by a video review by  K.G. Paul, M.D. A related article explores the pharmacology of thrombolytic agents. Classification of antiplatelet agents…

FDA video: interaction of IV ceftriaxone with calcium-containing products

The FDA updated the full prescribing information of ceftriaxone (Rocephin and generics). This is an update to a previous ( september 2007) alert on the risk of interaction between ceftriaxone and calcium-containing IV products, the 2007 alert was based on reported fatal cases in neonates.Continue Reading

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