SMC recommendations for doripenem : second or third line treatment of intra-abdominal infections

The Scottish Medicines Consortium issued an advice on the current indications for doripenem (Doribax):

Doripenem (Doribax) is accepted for restricted use within NHS Scotland for the treatment of complicated intra-abdominal infections in adults.
In patients with complicated intra-abdominal infection, doripenem is associated with clinical cure rates non-inferior to those of another carbapenem. Doripenem should be restricted to use as a second or third-line treatment of complicated intra-abdominal infections resistant to current conventional treatments. It should be used only on the advice of local microbiologists or specialists in infectious diseases.

Related papers on doripenem:

Doripenem: A Review of its Use in the Treatment of Bacterial Infections. Drugs:Volume 68(14)2008pp 2021-2057

Carbapenems in the USA: focus on doripenem. Expert Rev Anti Infect Ther. 2007 Oct;5(5):793-809.

Doripenem: A new carbapenem antibiotic a review of comparative antimicrobial and bactericidal activities. Ther Clin Risk Manag. 2007 October; 3(5): 789-794.

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