The PowerPoint files in this posts have been shared by R. Senthil Kumar M.D. , Dean of Basic Sciences and Pharmacology Professor at St. Matthew’s University School of Medicine. If you are interested in contributing to this blog, just send an e-mail to firstname.lastname@example.org
PPT 1: Introduction to cancer chemotherapy
Download PPT file: Cancer Chemotherapy 1
- Characteristics of cancer cells.
- The Goal of cancer treatments.
- Major approaches to therapy of cancers.
- Cell cycle and cancer chemotherapy.
- Cell cycle specific and cell cycle non-specific agents.
- Log kill hypothesis.
- Advantages of combination chemotherapy.
- Resistance to cytotoxic drugs (P-glycoprotein).
- Mechanisms of resistance to anticancer drugs.
- Adverse drug reactions of antineoplastic drugs in humans.
- Distinctive toxicities in some anticancer drugs.
- Prevention or management of induced toxicities.
- Anticancer drugs chart.
PPT 2: Anticancer drugs
Download PPT file: Cancer Chemotherapy 2
- Classification of anticancer drugs.
- Alkylating agents: mechanism of action.
- Alkylating agents indications.
- Cyclophosphamide: mechanisms of resistance,clinical uses and adverse drug reactions.
- Characteristics of: Cisplatin, procarbazine.
- Antimetabolites: mechanism of action, classification.
- Methotrexate: mechanisms of resistance, ADR.
- Leucovorin rescue, 6-Mercaptopurine,6-MP and allopurinol, Cytarabine, 5-fluorouracil.
- Plant alkaloids.
- Vinka alkaloids (Vinblastine and vincristine): ADR and mechanism of action.
- Etoposide and teniposide.
- Topoisomerase inhibitors.
- Paclitaxel and decetaxel.
- Anticancer antibiotics.
- Doxorubicin: ADR.
- Hormonal agents: glucocorticoids, tamoxifen.
- GnRH analogs for prostate cancer: leuprolide, gosarelin and naferelin.
- Aromatase inhibitors.
- Miscellaneous agents: asparaginase, imatinib, interferons and monoclonal antibodies.Trastuzumab
- FDA approved monoclonal antibodies used to treat cancer.
- Treatment of specific cancers.
Most of the figures used in this post are courtesy by Lippincott Williams and Wilkins and Mc Graw Hill Medical.
About the author
R. Senthil Kumar M.D is Dean of Basic Sciences and Associate Professor of Pharmacology & Clinical Therapeutics at St. Matthew’s University, School of Medicine, Cayman Islands.
Dr. Kumar has been distinguished with numerous awards, some of them include:
- 2006 and 2007 Prestigious Dean’s Award for teaching quality and student performance.
- 2007 and 2008 Golden Apple Award for best teacher, awarded by the American Medical Students Association – AMSA- ·
- 2007 Student Government Association Faculty Recognition Award for superior teaching and motivational abilities.