Cancer chemotherapy: PPT presentations

The PowerPoint files in this posts have been shared by R. Senthil Kumar M.D. ,  Dean of Basic Sciences and Pharmacology Professor at St. Matthew’s University School of Medicine. If you are interested in contributing to this blog, just send an e-mail to pharmamotion@gmail.com

PPT 1: Introduction to cancer chemotherapy

Download PPT file: Cancer Chemotherapy 1

  • Etiopathology.
  • Apoptosis.
  • Characteristics of cancer cells.
  • The Goal of cancer treatments.
  • Major approaches to therapy of cancers.
  • Cell cycle and cancer chemotherapy.
  • Cell cycle specific and cell cycle non-specific agents.
  • Log kill hypothesis.
  • Advantages of combination chemotherapy.
  • Resistance to cytotoxic drugs (P-glycoprotein).
  • Mechanisms of resistance to anticancer drugs.
  • Adverse drug reactions of antineoplastic drugs in humans.
  • Distinctive toxicities in some anticancer drugs.
  • Prevention or management of induced toxicities.
  • Anticancer drugs chart.

PPT 2: Anticancer drugs

Download PPT file: Cancer Chemotherapy 2

  • Classification of anticancer drugs.
  • Alkylating agents: mechanism of action.
  • Alkylating agents indications.
  • Cyclophosphamide: mechanisms of resistance,clinical uses and adverse drug reactions.
  • Characteristics of: Cisplatin, procarbazine.
  • Antimetabolites: mechanism of action, classification.
  • Methotrexate: mechanisms of resistance, ADR.
  • Leucovorin rescue, 6-Mercaptopurine,6-MP and allopurinol, Cytarabine, 5-fluorouracil.
  • Plant alkaloids.
  • Vinka alkaloids (Vinblastine and vincristine): ADR and mechanism of action.
  • Etoposide and teniposide.
  • Topoisomerase inhibitors.
  • Paclitaxel and decetaxel.
  • Anticancer antibiotics.
  • Doxorubicin: ADR.
  • Bleomycin.
  • Hormonal agents: glucocorticoids, tamoxifen.
  • GnRH analogs for prostate cancer: leuprolide, gosarelin and naferelin.
  • Aromatase inhibitors.
  • Miscellaneous agents: asparaginase, imatinib, interferons and monoclonal antibodies.Trastuzumab
  • FDA approved monoclonal antibodies used to treat cancer.
  • Treatment of specific cancers.

Most of the figures used in this post are courtesy by Lippincott Williams and Wilkins and Mc Graw Hill Medical.

About the author

R. Senthil Kumar

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R. Senthil Kumar M.D is Dean of Basic Sciences and Associate Professor of Pharmacology & Clinical Therapeutics at St. Matthew’s University, School of Medicine, Cayman Islands.

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Dr. Kumar has been distinguished with numerous awards, some of them include:

  • 2006 and 2007 Prestigious Dean’s Award for teaching quality and student performance.
  • 2007 and 2008 Golden Apple Award for best teacher, awarded by the American Medical Students Association – AMSA- ·
  • 2007 Student Government Association Faculty Recognition Award for superior teaching and motivational abilities.

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