Some key facts before you watch the video on aspirin absorption:

Source: University of Rhode Island Pharmacy Animations

Now, watch again the video paying attention to the following details.

image Non-ionized form a at the gastric lumen. It has 8 white spheres.

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image Ionized form of aspirin, in the bloodstream. It has 7 white spheres, this means that it has lost a proton.

Deprotonated form =  ionized = non-lipid soluble.

Now,since the drug is ionized it can’t diffuse back to the stomach and remains in the bloodstream.

This is ion trapping!

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Recommended reading

  • Pocket Guide: Pharmacokinetics Made Easy (2009)
  • Basic Clinical Pharmacokinetics (2009)
  • Concepts in Clinical Pharmacokinetics (2010)
  • Clinical Pharmacokinetics, 4th Edition (2008)
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