The PowerPoint files in this posts have been shared by R. Senthil Kumar M.D. , Dean of Basic Sciences and Pharmacology Professor at St. Matthew’s University School of Medicine. If you are interested in contributing to this blog, just send an e-mail to pharmamotion@gmail.com
PPT 1: Introduction to cancer chemotherapy
Download PPT file: Cancer Chemotherapy 1
- Etiopathology.
- Apoptosis.
- Characteristics of cancer cells.
- The Goal of cancer treatments.
- Major approaches to therapy of cancers.
- Cell cycle and cancer chemotherapy.
- Cell cycle specific and cell cycle non-specific agents.
- Log kill hypothesis.
- Advantages of combination chemotherapy.
- Resistance to cytotoxic drugs (P-glycoprotein).
- Mechanisms of resistance to anticancer drugs.
- Adverse drug reactions of antineoplastic drugs in humans.
- Distinctive toxicities in some anticancer drugs.
- Prevention or management of induced toxicities.
- Anticancer drugs chart.
PPT 2: Anticancer drugs
Download PPT file: Cancer Chemotherapy 2
- Classification of anticancer drugs.
- Alkylating agents: mechanism of action.
- Alkylating agents indications.
- Cyclophosphamide: mechanisms of resistance,clinical uses and adverse drug reactions.
- Characteristics of: Cisplatin, procarbazine.
- Antimetabolites: mechanism of action, classification.
- Methotrexate: mechanisms of resistance, ADR.
- Leucovorin rescue, 6-Mercaptopurine,6-MP and allopurinol, Cytarabine, 5-fluorouracil.
- Plant alkaloids.
- Vinka alkaloids (Vinblastine and vincristine): ADR and mechanism of action.
- Etoposide and teniposide.
- Topoisomerase inhibitors.
- Paclitaxel and decetaxel.
- Anticancer antibiotics.
- Doxorubicin: ADR.
- Bleomycin.
- Hormonal agents: glucocorticoids, tamoxifen.
- GnRH analogs for prostate cancer: leuprolide, gosarelin and naferelin.
- Aromatase inhibitors.
- Miscellaneous agents: asparaginase, imatinib, interferons and monoclonal antibodies.Trastuzumab
- FDA approved monoclonal antibodies used to treat cancer.
- Treatment of specific cancers.
Most of the figures used in this post are courtesy by Lippincott Williams and Wilkins and Mc Graw Hill Medical.
About the author
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R. Senthil Kumar M.D is Dean of Basic Sciences and Associate Professor of Pharmacology & Clinical Therapeutics at St. Matthew’s University, School of Medicine, Cayman Islands.
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Dr. Kumar has been distinguished with numerous awards, some of them include:
- 2006 and 2007 Prestigious Dean’s Award for teaching quality and student performance.
- 2007 and 2008 Golden Apple Award for best teacher, awarded by the American Medical Students Association – AMSA- ·
- 2007 Student Government Association Faculty Recognition Award for superior teaching and motivational abilities.