Hematology, cancer chemotherapy and related
Articles filed under Hematology, cancer chemotherapy and related.
Imatinib (Gleevec) pharmacology: mechanism of action and therapeutic considerations
Imatinib mesylate is a small-molecule tyrosine kinase inhibitor that was initially developed as a 2-phenylaminopyrimidine derivative specific for PDGFR. Imatinib was subsequently found to be a potent inhibitor of ABL kinases, including the BCR-ABL fusion protein generated as a result of the t(9;22) chromosomal translocation (Philadelphia chromosome) found in chronic myelogenous leukemia (CML), and was