PowerPoint presentation on diuretics: MOA, indications, side effects and therapeutic considerations
The following set of lectures has been created by Dr. Edwin Jackson and were published in the Division for Cardiovascular Pharmacology, a branch of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Part 1: How diuretics work Download: DIURETICS Part 1 – How they work. PPT file Part 2: What do diuretics do Na-K-2Cl […]
Video animation on renal physiology and diuretics mechanism of action.
Mechanism of action of loop diuretics ( Source: Bertram Katzung, Basic and Clinical Pharmacology, Mc Graw Hill Medical, 2007): Pharmacodynamics These drugs inhibit NKCC2, the luminal Na+/K+/2Cl– transporter in the thick ascending limb of Henle’s loop. By inhibiting this transporter, the loop diuretics