In this video I describe the 4 dopamine pathways relevant to the mechanism of action and adverse effects of antipsychotic drugs.
Outline:
- General overview of dopaminergic pathways
- Mesolimbic pathway & positive symptoms of schizophrenia
- Mesocortical pathway: negative & cognitive symptoms
- Nigrostriatal pathway & EPS
- Tuberoinfundibular pathway & prolactin release
- Summary
References and further reading
Stahl, S. Stahl’s Essential Psychopharmacology: Neuroscientific Basis & Practical Applications. 3rd ed. Cambridge University Press, 2008.
Golan D, Tashjian AH, Armstrong EJ. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2011.