A video on Mu, Delta, Kappa and ORL1 receptors

By Flavio Guzmán, MD
This lecture discusses the following topics:

Part 1: Classification and cellular actions

Provides an introduction to the classification of  opioid receptors,  it also discusses the cellular effects of  opioid receptor activation (presynaptic inhibition of neurotransmitter release).

Part 2: Mu, kappa and delta receptors (including agonists and antagonists)

Part 2 lists the most relevant agonists and antagonists for the different subtypes of opioid receptor, then effects upon activation (opioid physiology) are reviewed.

Part 3: ORL1, nociceptin or orphanin FQ receptor

Part 3 is an overview on the recently discovered ORL1 receptor.

PowerPoint presentation

If you prefer to review the figures at your own pace you can review the PPT slide by slide:

References and further reading

Katzung, B. Basic and Clinical Pharmacology. 11th ed. McGraw Hill Medical, 2009

Koneru A, Sreemantula S, Rizwan. Endogenous Opioids: Their Physiological Role and Receptors. Global J. Pharmacol., 3 (3): 149-153, 2009

McDonald J, Lambert DJ. Opioid Receptors. Continuing Education in Anaesthesia, Critical Care & Pain 2005 5:1

Trescot A, Sukdeb D. Opioid Pharmacology. Pain Physician 2008; 11:S133-S153

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