SMC: Zoledronic acid (Aclasta) not recommended for treatment of osteoporosis in men

This is the advice published by the Scottish Medicines Consortium about the use of zoledronic acid for the treatment of osteoporosis in men. ADVICE: in the absence of a submission from the holder of the marketing authorisation. zoledronic acid 5mg (Aclasta®) is not recommended for use within NHSScotland for the treatment of osteoporosis in men […]

Pharmacodynamics (drug receptor interactions): power point presentation

This document has been uploaded to Scribd by Dr. Robert L. Copeland, Pharmacology Professor at Howard University. It deals with basic principles of pharmacodynamics like: Concept of specific drug receptors, Receptor Types, Ion-channel-linked receptors, G-protein-linked receptors, Enzyme-linked receptors, Intracellular receptors, Log Dose-Response Curve, Agonists (or Full Agonists), additivity and sinergism. You can download the power […]

USMLE-like pharmacology quiz. Part 4: pharmacodynamics

The following are multiple choice questions in a style similar to those included in the USMLE step 1. The main topic here is: pharmacodynamics. This quiz has been uploaded to Scribd by medical student James Lamberg. The correct answers can be found in link at the end of this post. Note: the words underlined don’t […]

USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug metabolism)

The following are multiple choice questions in a style similar to those included in the USMLE step 1. The main topic here is: pharmacokinetics (drug metabolism). This quiz has been uploaded to Scribd by medical student James Lamberg. The correct answers can be found in link at the end of this post. Note: the words […]

USMLE-like pharmacology quiz. Part 1: general principles

The following are multiple choice questions in a style similar to those included in the USMLE step 1. The main topic here is basic principles of pharmacology. This quiz has been uploaded to Scribd by medical student James Lamberg. The answers can be found in link at the end of this post. Note: the words […]

Aliskiren (Rasilez) for essential hypertension: not recommended by the NHS Scotland

The Scottish Medicines Consortium issued on 5th December 2008 an advice on aliskiren (Rasilez, Tekturna in the US): Aliskiren (Rasilez) is not recommended for use within NHS Scotland for the treatment of essential hypertension. Aliskiren has shown comparable efficacy to other antihypertensive agents in terms of blood pressure reduction, though its effects on mortality and […]

Inferferons: definition and mechanism of action explained in a flash animation

What are interferons? From Wikipedia: Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferons belong to the large class of glycoproteins known as cytokines. Interferons are produced by a wide variety of cells […]

Rivaroxaban (Xarelto) for the prevention of venous thromboembolism (VTE): SMC review

The  Scottish Medicines Consortium issued on 7th November, 2008 an advice on rivaroxaban (Xarelto): ADVICE: following a full submissionrivaroxaban (Xarelto®) is accepted for use  within NHS Scotland for the prevention of venous thromboembolism (VTE) in adult patients undergoing elective hip or knee replacement surgery.In three large phase III studies in patients undergoing either total knee […]

Natalizumab (Tysabri) for multiple sclerosis: AAN guideline and recommendations

The American Academy of Neurology (AAN) published via the National Guideline Clearinghouse a set of recommendations for the use of the monoclonal antibody Natalizumab (Tysabri) for multiple sclerosis: MAJOR RECOMMENDATIONS Definitions of the strength of the recommendations (A, B, C, U) and classification of the evidence (Class I through Class IV) are provided at the […]

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