Pharmacokinetics video animation. IV administration.

Recommended pharmacokinetics reading Pocket Guide: Pharmacokinetics Made Easy (2009) Basic Clinical Pharmacokinetics (2009) Concepts in Clinical Pharmacokinetics (2010) Clinical Pharmacokinetics, 4th Edition (2008)

Sitaxentan (Thelin) for pulmonary hypertension. Australian Prescriber review

From Australian Prescriber: Sitaxentan sodium Thelin (CSL) 100 mg tablets Approved indication: pulmonary hypertension Australian Medicines Handbook section 6.7.2 Pulmonary hypertension results from intimal hypertrophy narrowing small pulmonary arteries. The increase in pulmonary vascular resistance leads to right ventricular failure. Primary pulmonary hypertension is less common than the pulmonary hypertension associated with other conditions such […]

Second messenger system animation. IP3 signal transduction pathway

Created by Department of Biology, Davidson College, Davidson, NC 28036 More information about inositol trisphosphate from the WIkipedia article about IP3 : Inositol trisphosphate or inositol 1,4,5-trisphosphate (also commonly known as triphosphoinositol; abbreviated InsP3 or IP3), together with diacylglycerol, is a secondary messenger molecule used in signal transduction in biological cells. It is made by […]

Pharmacodynamics definitions. Receptor desensitization

The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Desensitization: A decline in the response to repeated or sustained application of an agonist that is a consequence of changes at the level of the receptor. The copyright of the text is hold by […]

Degarelix (Firmagon) for prostate cancer: now approved by FDA

Related to EMEA’s positive opinion on degarelix (Firmagon) for prostate cancer, FDA issues this press release dated Dec. 29, 2008: FDA Approves Drug for Patients with Advanced Prostate Cancer The U.S. Food and Drug Administration recently approved the injectable drug degarelix, the first new drug in several years for prostate cancer.  

Ibandronic acid (Bondronat) for the treatment of hypercalcaemia and bony metastases. Australian Prescriber review

From Australian Prescriber: Ibandronic acid Bondronat (Hospira) vials containing 6 mg/6 mL Approved indications: hypercalcaemia, bony metastases of breast cancer Australian Medicines Handbook section 10.3.1 Bisphosphonates can reduce the hypercalcaemia of malignant disease by inhibiting the resorption of bone. Clodronate, pamidronate and zoledronic acid are already available for this indication. They are now

Temsirolimus (Torisel): kinase inhibitor for the treatment of advanced renal cell carcinoma. Australian Prescriber review

From Australian Prescriber: Temsirolimus Torisel (Wyeth) vials containing 25 mg/mL concentrate Approved indication: advanced renal cell carcinoma Australian Medicines Handbook section 14.2.3 About 30% of patients with renal cell carcinoma have advanced or metastatic disease at the time of diagnosis. Chemotherapy is generally ineffective and nephrectomy is the mainstay of treatment for disease confined to […]

Paricalcitol (Zemplar): a vitamin D analogue for the treatment of secondary hyperparathyroidism. Australian Prescriber review

From Australian Prescriber: Paricalcitol Zemplar (Abbott) 1 microgram, 2 microgram and 4 microgram capsules 5 microgram/mL in 1 mL and 2 mL ampoules Approved indication: secondary hyperparathyroidism Australian Medicines Handbook section 10.3.2 In chronic renal failure there is reduced production of calcitriol, the active form of vitamin D. This affects calcium homeostasis and leads to […]

Panitumumab (Vectibix) for metastatic colorectal carcinoma. Australian Prescriber review

From Australian Prescriber: Panitumumab Vectibix (Amgen) vials containing 20 mg/mL in 5 mL, 10 mL or 20 mL volume Approved indication: metastatic colorectal carcinoma Australian Medicines Handbook section 14.2.1 Panitumumab is a humanised monoclonal antibody for the treatment of metastatic colorectal carcinomas expressing the epidermal growth factor receptor. It is indicated for patients whose tumours […]

Anti-thymocyte globulin (Thymoglobuline) for renal transplant rejection and aplastic anaemia. Australian Prescriber review

From Australian Prescriber: Anti-thymocyte globulin Thymoglobuline (Genzyme) vials containing 25 mg freeze-dried powder Approved indication: renal transplant rejection and aplastic anaemia Australian Medicines Handbook section 14.5.3 Anti-thymocyte globulin is indicated for the prophylaxis of renal graft rejection as well as the treatment of steroid-resistant renal transplant rejection. Kidney transplantation is the treatment of choice for […]

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