Latest posts
Page 20 of 26
Pharmacodynamics. Cross tolerance definition
The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Cross-Tolerance: Tolerance to a drug that generalizes to drugs that are chemically related of that produce similar affects. For example, a patient who is tolerant to heroin will also exhibit cross-tolerance to morphine. The
Pharmacokinetics. Compartment(s) definition
The following pharmacology definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Compartment(s): The space or spaces in the body, which a drug appears to occupy after it has been absorbed. Pharmacokinetic compartments are mathematical constructs and need not correspond to the fluid volumes of the
Clinical trials. Cross-Over Experiment definition
The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Cross-Over Experiment: A form of experiment in which each subject receives the test preparation at least once, and every test preparation is administered to every subject. At successive experimental sessions each preparation is “crossed-over”
EMEA: marketing authorisation of Nespo (darbepoetin alfa) withdrawed
EMEA public statement dated 16 December 2008: PUBLIC STATEMENT ONNespo (darbepoetin alfa) WITHDRAWAL OF THE MARKETING AUTHORISATION IN THE EUROPEAN UNION On 8 June 2001 the European Commission issued a marketing authorisation valid throughout the European Union for the medicinal product Nespo, darbepoetin alfa, which had been approved for the treatment of symptomatic anaemia associated
EMEA: marketing authorisation of Neupopeg (pegfilgrastim) withdrawed
Public statement dated 16 December 2008: PUBLIC STATEMENT ON Neupopeg (pegfilgrastim) WITHDRAWAL OF THE MARKETING AUTHORISATION IN THE EUROPEAN UNION On 22 August 2002 the European Commission issued a marketing authorisation valid throughout the European Union for the medicinal product Neupopeg, pegfilgrastim, which had been approved for the reduction in the duration of neutropenia and the incidence
Pharmacological efficacy and safety. Clinical therapeutic index definition.
The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Clinical Therapeutic Index: Some indices of relative safety or relative effectiveness cannot be defined explicitly and uniquely, although it is presumed that the same quantifiable and precise criteria of efficacy and safety will be
AHRQ Comparative Effectiveness Review. Premixed insulin analogues for adults with type 2 diabetes.
From the AHRQ newsletter, December 18, 2008, Issue # 2. Comparative Effectiveness Review. Premixed Insulin Analogues for Adults With Type 2 Diabetes Premixed insulin preparations are an alternative that may permit a smaller number of daily insulin injections. Although oral diabetes medicines are used as first-line treatments in patients with type 2 diabetes, insulin is
Alfuzosin does not improve symptoms of chronic prostatitis- chronic pelvic pain syndrome
From JournalWatch: Alpha-Blocker Does Not Ease Symptoms of Chronic Prostatitis Alfuzosin, an alpha-adrenergic–receptor blocker, does not improve symptoms in men with chronic prostatitis–chronic pelvic pain syndrome, according to a New England Journal of Medicine study.
Pharmacology mnemonic. Inhalational anaesthetics
Inhalational anesthetics SHINE: Sevoflurane Halothane Isoflurane Nitrous oxide Enflurane Thanks to MedExcel
Pharmacokinetics. First order kinetics definition and animation.
The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. First Order Kinetics: According to the law of mass action, the velocity of a chemical reaction is proportional to the product of the active masses (concentrations) of the reactants.
Pharmacology mnemonics. Direct sympathomimetic catecholamines
Direct sympathomimetic catecholamines DINED: Dopamine Isoproterenol Norepinephrine Epinephrine Dobutamine Thanks to MedExcel
Pharmacology mnemonic. Anticholinergic side effects
Anticholinergic side effects “Know the ABCD’S of anticholinergic side effects”: Anorexia Blurry vision Constipation/ Confusion Dry Mouth Sedation/ Stasis of urine Thanks to MedExcel
Pharmacokinetics. A definition of clearance (renal and non renal)
The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Clearance: The clearance of a chemical is the volume of body fluid from which the chemical is, apparently, completely removed by biotransformation and/or excretion, per unit time. In fact, the chemical is only partially
Pharmacodynamics. Ceiling definition
The following pharmacological definition has been taken from the Pharmacology and Experimental Therapeutics Department Glossary at Boston University School of Medicine. Ceiling: The maximum biological effect that can be induced in a tissue by a given drug, regardless of how large a dose is administered.
EMEA press release: CHMP adopted positive opinion about mifamurtide (Mepact) for the treatment of osteosarcoma
EMEA press release informing the CHMP positive opinion about mifamurtide (Mepact), for the treatment of high grade resectable non metastatic osteosarcoma. COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE SUMMARY OF POSITIVE OPINION for MEPACT International Nonproprietary Name (INN): mifamurtide On 18 December 2008 the Committee for Medicinal Products for Human Use (CHMP) adopted a positive