Dr. Edwin Jackson, from the ASPET Division of Cardiovascular Pharmacology, prepared the following PowerPoint lecture on pharmacodynamics, mainly about the dose-effect relationship. The approach is very interesting since its quite clear and simple, but still accurate and thorough.
- Dose-effect relationships
- What determines the dose-effect relationship?
- What is the relationship between [drug] and [drug receptor]?
- What is the concentration-effect relationship?
- EC50
- Spare receptors
- Potency
- Full agonist
- Partial agonist
- Surmountable antagonist
- What is the effect of blocking drugs on concentration-response curves?
- Characteristics of insurmountable antagonists
- What is a quantal concentration or dose response curve?