Thrombin inhibition: video animation explaining bivalirudin (Angiomax, Angiox) mechanism of action
Chemistry and mechanism of action of bivalirudin (Angiox, Angiomax), from Wikipedia: Chemically it constitutes a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis). Both bivalirudin and hirudin directly inhibit thrombin by specifically binding as well to the catalytic site and to the anion-binding exosite of […]
Bivalirudin (Angiox) for acute coronary syndromes: SMC review
The Scottish Medicines Consortium issued on 7th December, 2008 an advice on bivalirudin (Angiox): Bivalirudin (Angiox) is accepted for restricted use within NHS Scotland for the treatment of adult patients with acute coronary syndromes (unstable angina/non-ST segment elevation myocardial infarction) planned for urgent or early intervention. It is restricted to use in patients who would […]