PPIs reduce the effectiveness of clopidogrel (Plavix)
Pharmamotion has now a new page containing updates on clopidogrel – PPI interactions. The latest edition of the monthly newsletter from the Medicines and Healthcare products Regulatory Agency has issued a drug safety advice on the interaction between the antiplatelet drug clopidogrel (Plavix) and PPIs. They conclude that available data supports a clinically significant interaction […]
Proton pump inhibitors (PPIs) mechanism of action. A video animation
Mechanism of action of PPI’s. Source: Wikipedia Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase, or more commonly just gastric proton pump) of the gastric parietal cell. The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H+ ions into the […]