FDA updated information about a safety review of Ezetimibe/Simvastatin (Vytorin), Ezetimibe (Zetia), and Simvastatin (Zocor)
FDA updated yesterday ( January 8, 2009) information related to their review of the ENHANCE trial: On January 25, 2008, FDA announced that it would be reviewing data from the ENHANCE trial (Effect of Combination Ezetimibe and High-Dose Simvastatin vs. Simvastatin Alone on the Atherosclerotic Process in Patients with Heterozygous Familial Hypercholesterolemia). (http://www.fda.gov/cder/drug/early_comm/ezetimibe_simvastatin.htm). Preliminary results from this […]
Pharmacology mnemonic. HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions
Pharmacology mnemonic about: HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions HMG CoA: Side effects: H epatotoxicity M yositis [aka rhabdomyolysis] _ Contraindications: G irl during pregnancy/G rowing children _ Interactions: C oumarin/ C yclosporine Also, check a related animation on their mechanism of action. Thanks to MedExcel
Cheap generic statins are just as successful at achieving cholesterol lowering targets
Can cheap generic statins achieve national cholesterol lowering targets? Duncan Petty , David Lloyd 1 School of Healthcare, University of Leeds, Leeds; 1 Prescribing Support Unit, The Information Centre for Health and Social Care, Leeds, UK Objectives: The Department of Health in England recommend that simvastatin and pravastatin should be prescribed in at least 69% […]
Statins: mechanism of action and side effects
An overview on the mechanism of action of statins: HMG CoA reductase inhibitors,or statins are widely prescribed drugs. They are indicated for the treatment of hipercholesterolemia, a condition that increases cardiovascular risk. Currently, the drugs of this group that are available are: Atorvastatin Fluvastatin Lovastatin Mevastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin Mechanism of action. Animation explained […]