Category Archives: NSAIDS

Video on aspirin pharmacokinetics: the role of the ion trapping phenomenon

Some key facts before you watch the video on aspirin absorption:

  • Aspirin is a weak acid (pKa 3.4).
  • Acidic drugs in an acidic environment (like gastric lumen) are most likely to be in their neutral form ( non-ionized )
  • Non-ionized drugs are more lipid soluble. Hence, they can be readily absorbed
  • Since aspirin is a weak acid and gastric pH is an acidic environment,  it can be readily absorbed.
  • Bloodstream has a pH of around 7.4, therefore aspirin tends to be ionized. This prevents the drug from diffusing back to the stomach.

Source: University of Rhode Island Pharmacy Animations

Now, watch again the video paying attention to the following details.

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Updated SIGN clinical guideline: Pain management in adults with cancer

The Scottish Intercollegiate Guidelines Network (SIGN) updated a clinical guideline entitled “Control of pain in adults with cancer”.  An outline of the contents (drug therapy related) in this guideline for the treatment of cancer induced pain include: Principles of pain management: introduction, World Health Organization cancer pain relief programme, using the WHO ladder. Treatment with…

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