Category Archives: Benzodiazepines and Z-drugs

Benzodiazepines mechanism of action

Benzodiazepines and GABA receptors: an animation on their mechanism of action Gamma amino butyric acid (GABA) is an inhibiting neurotransmitter that is present on human brains. As shown in the animation, gamma amino butyric acid promotes opening of a postsynaptic receptor, the GABA-A receptor. This opening leads to a increased conductance to cloride ions, whichContinue Reading

MCQs for USMLE review on psychopharmacology: antipsychotics, benzodiazepines, antidepressants and lithium

These pharmacology MCQs from the UMKC School of Medicine have a different degree of difficulty, but are useful to review pharmacology of psychotropics. Psychotropics Item Number: 11667 correct answer: 4 category: Psychotropics 1. The symptoms of tardive dyskinesia will acutely improve with: 1. administration of diphenhydramine 2. administration of amantadine 3. administration of bromocriptine 4.Continue Reading

Risk of midazolam overdose: NHS alert

This is a rapid response report from the National Patient Safety Agency (A branch of NHS) about the risk of midazolam (Dormicum, Hypnovel, Midacum and Versed) overdose Reducing risk of overdose with midazolam injection in adults Issue Some adult patients are being overdosed with midazolam injection when used for conscious sedation. The presentation of high strengthContinue Reading

Mnemonic to remember which benzodiazepines don’t have hepatic metabolism

Benzodiazepines: ones not metabolized by the liver (safe to use in liver failure) LOT: Lorazepam Oxazepam Temazepam Thanks to MedExcel Remember to check the animation on the mechanism of action of benzodiazepines.Continue Reading

Zolpidem, zoplicone and zaleplon (z-drugs) side effects profile: Australian Prescriber press release

Hypnotic hazards and effects of z-drugs immeasurable “It is difficult to know the extent of use and adverse effects of zolpidem and other z-drugs (zopiclone and zaleplon) because they have never been listed on the Australian Pharmaceutical Benefits Scheme, senior Sleep Disorders Physician Dr Les Olson writes in the latest edition of Australian Prescriber.Continue Reading

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