Mechanism of action video animation: ACE inhibitors, Angiotensin II receptor blockers (ARBs) and the Renin Angiotensin Aldosterone System

Also, a diagram of the Renin Angiotensin Aldosterone System (RAAS System) physiology.

Drugs acting on the Renin Angiotensin Aldosterone System.

ACE Inhibitors.

List of agents

Sulfhydryl-containing agents

Captopril (Capoten), Zofenopril

Dicarboxylate-containing agents

Enalapril (Vasotec, Renitec)

Ramipril (Altace, Tritace, Ramace, Ramiwin)

Quinapril (Accupril)

Perindopril (Coversyl, Aceon)

Lisinopril (Lisodur, Lopril, Novatec, Prinivil, Zestril)

Benazepril (Lotensin)

Phosphonate-containing agents

Fosinopril (Monopril) is the only member of this group

Angiotensin II receptor blockers (ARBs)

Mode of action. Source: Wikipedia

These substances are AT1-receptor antagonists – that is, they block the activation of angiotensin II AT1 receptors. Blockade of AT1 receptors directly causes vasodilation, reduces secretion of vasopressin, reduces production and secretion of aldosterone, amongst other actions – the combined effect of which is reduction of blood pressure.

List of agents

Losartan (Cozaar)

Irbesartan ( Aprovel, Karvea, and Avapro)

Olmesartan (Benicar, Olmetec)

Candesartan (Blopress, Atacand, Amias, and Ratacand)

Valsartan (Diovan, Valtan, Valtan)

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