Benzodiazepines and GABA receptors: an animation on their mechanism of action Gamma amino butyric acid (GABA) is an inhibiting neurotransmitter that is present on human brains. As shown in the animation, gamma amino butyric acid promotes opening of a postsynaptic receptor, the GABA-A receptor. This opening leads to a increased conductance to cloride ions, which […]
Thrombolytic agents are used to lyse already formed blood clots in clinical settings where ischemia may be fatal ( acute mycardial infarction, pulmonary embolism, ischemic stroke, and arterial thrombosis). Very precise indications rule the use of these drugs, which are not free from serious side effects ( bleeding). Outline: Mechanism of action of thrombolytic therapy […]
The following set of lectures has been created by Dr. Edwin Jackson and were published in the Division for Cardiovascular Pharmacology, a branch of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Why study autonomic pharmacology? Outline of slides: Parasympathetic Ganglionic Synapse, Parasympathetic Organ Synapse, Sympathetic Ganglionic Synapse, Sympathetic Ganglionic Synapse, How do drugs […]
Nucleoside analog reverse transcriptase inhibitors (NRTIs) are nucleoside analogues that act as competitive inhibitors of HIV-1 reverse transcriptase. As shown in the animation, these drugs compete with nucleoside triphosphates for access to reverse transcriptase. All NRTIs lack a 3-hydroxyl group; thus, their incorporation into a growing DNA chain results in its termination. They require intracytoplasmic […]
This post is an overview on antiplatelet drugs, we will focus on the classification of agents and their mechanism of action. The most relevant facts related to therapeutics will also be discussed here, followed by a video review by K.G. Paul, M.D. A related article explores the pharmacology of thrombolytic agents. Classification of antiplatelet agents […]
Video lecture on the different classes of drugs used as lipid-lowering agents. Features an overview on their main characteristics as well as their mechanisms of action.
Overview on the mechanism of action, indications, adverse effects profile of prasugrel (Efient in the EU, Effient in the USA). PowerPoint on the TIMI TRITON 38 trial.
PPT files on antipsychotics (neuroleptics): it gathers lectures from different specialties (Family Medicine, Psychiatry) highlighting key pharmacological pearls.
Video animation showing the mechanism of action of Botox (Botulinum toxin type A) on neuromuscular neurotransmission.
A video by National Geographic discusses the mechanisms of addiction of Methamphetamine (also known as Meth and Tik).
Etanercept, infliximab and adalimumab are TNF alpha blockers. Learn about TNF alpha in inflammation. Mechanism of action, therapeutic uses and adverse effects profile of these drugs.
PPT lectures on opioids: mechanism of action in analgesia (mu, kappa and delta receptors), pharmacological effects of morphine and antagonists.
Prescribing information, mechanism of action, approved indications and videos on Avastin (bevacizumab) for glioblastoma multiforme.
Animation on coagulation physiology and the mechanism of action of glycoprotein IIb/IIIa antagonists
Animation on coagulation physiology and mechanism of action of Gp IIb/IIIa inhibitors (abciximab, eptifibatide and tirofiban) and other antiplatelet drugs.