PowerPoint on neuromuscular blockers pharmacology: mechanism of action, classification, uses, interactions and more

The following pharmacology lecture was developed by the Department of Pharmacology and Therapeutics, at American University of Beirut.

Download PPT file: Neuromuscular Blockers

An outline of the slideshow content:

  • Neuromuscular blockers differ from each other in: • Mechanism of action • Duration of action • Speed of onset and offset of action • Selectivity of action and safety margin • Adverse effects
  • Classification of Blockers
  • Site of Action
  • Non-depolarizing Block
  • Comparison of Competitive and Depolarizing Blocking Agents
  • Sequence of Paralysis: Fingers, orbit (small muscles) limbs neck Trunk Diaphragm,  Intercostals. Recovery in Reverse
  • Adverse Effects/Toxicity
  • Dual Block by Depolarizing Agents
  • Other Effects of Neuromuscular Blockers
  • Hemodynamic Effects of d-Tubocurarine and Pancuronium CO

Non-depolarizing blocking agents

Atracurium (Tracrium), Cisatracurium (Nimbex), Doxacurium (Nuromax), Gallamine (Flaxedil), Mivacurium (Mivacron), Pancuronium (Pavulon), Pipecuronium, Rapacuronium (Raplon)

Depolarizing blocking agents

Succinylcholine, Decamethonium

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