Cardiovascular
Articles filed under Cardiovascular. Part of By specialty.
Warfarin PowerPoint presentation
PPT on Warfarin pharmacotherapy. Discusses mechanism of action, dosing and target INRs, drug and food interactions, and patient counseling.
Alpha receptors
Alpha adrenergic receptors location and effects highlighted in pharmacology charts.
The coagulation cascade
Coagulation cascade: several resources (videos, animations and tutorials) depicting coagulation factors and pathways.
Hypertension management: pharmacotherapy lecture notes (PDF)
Phharmacological management of hypertension: by the Pharmacology OpenCourseWare initiative at Harvard Medical School – MIT.
Calcium channel blockers: classification, mechanism of action and indications
Overview on calcium channel blockers, in this first part we will discuss their classification, mechanism of action as well as clinical indications.
Drug therapy for heart failure: PowerPoint presentations
Both lectures provide an introduction on clinical features of the disease and its physiopathology, later they review the most relevant pharmacological properties of each drug class.
COGENT trial: no clopidogrel-PPIs interaction
According to the results of the COGENT trial, the combination of the antiplatelet clopidogrel and the PPI omeprazole does not produce clinically relevant cardiovascular interactions.
Prasugrel (Effient): mechanism of action, indications and adverse effects
Overview on the mechanism of action, indications, adverse effects profile of prasugrel (Efient in the EU, Effient in the USA). PowerPoint on the TIMI TRITON 38 trial.
PPIs reduce the effectiveness of clopidogrel (Plavix)
Pharmamotion has now a new page containing updates on clopidogrel – PPI interactions. The latest edition of the monthly newsletter from the Medicines and Healthcare products Regulatory Agency has issued a drug safety advice on the interaction between the antiplatelet drug clopidogrel (Plavix) and PPIs. They conclude that available data supports a clinically significant interaction
ACE inhibitors and angiotensin II receptor blockers should be avoided in pregnancy and during breastfeeding
UK’s MHRA: do not to use ACE inhibitors and angiotensin II receptor antagonists while breastfeeding. Hypertension Journal reviews ACEI toxicity in pregnancy.
Cardiac arrhythmias made easy: a video you’ll never forget
Easy to understand video on cardiac electrophysiology. A cardiology professor acts the main types of cardiac arrhythmias (including atrial fibrillation and flutter).
Animation on coagulation physiology and the mechanism of action of glycoprotein IIb/IIIa antagonists
Animation on coagulation physiology and mechanism of action of Gp IIb/IIIa inhibitors (abciximab, eptifibatide and tirofiban) and other antiplatelet drugs.
Digoxin Mechanism of Action: Animated Tutorial
Mechanism of action of digoxin (Lanoxin) reviewed: animation and excerpts of a pharmacology textbook on the pharmacological effects of this cardiac glycoside for heart failure.
MCQs on cardiovascular pharmacology. Pre-test practice review: vasodilators and inotropes
MCQs on cardiovascular pharmacology: inotropics and vasodilators. For USMLE step 1 review. More MCQs on other pharmacological topics.
Warfarin dosing: the role of genes
Warfarin dosing: the genes VKORC1, CYP2C9, CYP4F2 are determinants in the dosing of warfarin. Role in clinical practice of pharmacogenomics: genetic testing to guide warfarin therapy.