Animation: NRTIs mechanism of action

Nucleoside analog reverse transcriptase inhibitors (NRTIs) are nucleoside analogues that act as competitive inhibitors of HIV-1 reverse transcriptase. As shown in the animation, these drugs compete with nucleoside triphosphates for access to reverse transcriptase. All NRTIs lack a 3-hydroxyl group; thus, their incorporation into a growing DNA chain results in its termination. They require intracytoplasmic […]

Clinical guidelines on pneumonia management and treatment

This post features two clinical guidelines on the management of community acquired pneumonia.

The British Thoracic Society updated this year many recommendations, including when to order a chest X-ray, and antibiotic management.

The guidelines issued by the Infectious Diseases Society of America and the AmericanThoracic Society have relevant recommendations concerning empirical antimicrobial therapy and its duration.

Vancomycin mechanism of action: an animation

Vancomycin is a tricyclic glycopeptide that has gained clinical importance thanks to its effectiveness against organisms such as MRSA and enterococci. It has activity against Gram-positive rods and cocci, Gram-negative rods are resistant to its bactericidal action. Some clinical uses of IV vancomycin include treatment of infective endocarditis and sepsis caused by MRSA. Since vancomycin […]

Clinical guidelines on the management of hepatitis B infection

New clinical practice guidelines on the management of hepatitis B were published this year in Annals of Internal Medicine. These guidelines are the result of the latest National Institutes of Health Consensus Development Conference Statement on hepatitis B.

SMC recommendations for doripenem : second or third line treatment of intra-abdominal infections

The Scottish Medicines Consortium issued an advice on the current indications for doripenem (Doribax): Doripenem (Doribax) is accepted for restricted use within NHS Scotland for the treatment of complicated intra-abdominal infections in adults. In patients with complicated intra-abdominal infection, doripenem is associated with clinical cure rates non-inferior to those of another carbapenem. Doripenem should be […]

Study aids for antifungals pharmacology: diagram showing MOA and table summary for activity spectrum

The following images created by the Dept. of Pharmacology at University of Utah are great for reviewing antifungals before a test like USMLE: Diagram of sites of action of major antifungals Table: Spectrum of activity of antifungal agents Agents: Amphotericin, nystatin, flucytosine, azoles: miconazole, ketoconazole, itraconazole, fluconazole, griseofulvin Technorati : Antifungals, mechanism of action, tables

Etravirine (Intelence) for HIV infection: not recommended by the Scottish Medicines Consortium

This is an excerpt from the Scottish Medicines Consortium (SMC) advice on etravirine (Intelence). ADVICE: following a full submission etravirine  (Intelence),  in  combination  with  a  boosted  protease  inhibitor and  other antiretroviral medicinal  products,  is not  recommended  for use within NHS Scotland  for  the treatment  of  human  immunodeficiency  virus  type  1  (HIV-1)  infection  in  antiretroviral treatment-experienced […]

Xigris (Drotrecogin alfa activated): concerns of serious bleeding and increased death trigger FDA safety review

On February 4th, 2009 the FDA announced an ongoing safety review of Xigris (Drotrecogin alfa [activated]). An introduction from Wikipedia: Drotrecogin alfa (activated) (Xigris, marketed by Eli Lilly and Company) is a recombinant form of human activated protein C ( rhAPC) that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties. Drotrecogin alpha (activated) belongs to the class […]

Hypersensitivity reactions to Abacavir (Ziagen, Trizivir and Epzicom): FDA does not recommended skin patch for screening

FDA  recommends the clinical diagnosis of hypersensitivity reactions to Abacavir, instead of using the skin patch testing. From the FDA Drug Safety Newsletter Vol. 2 Number 1, 2009: Abacavir (Marketed as Ziagen) and Abacavir-Combination Products (Marketed as Trizivir and Epzicom): Hypersensitivity Reaction, HLA-B*5701, and Skin Patch Testing Abstract: As of July 2008, the Boxed Warning […]

HIV fusion inhibitors mechanism of action. A video animation

This animation represents the third step in HIV cell entry: fusion. It identifies gp41 as a drug target (Enfuvirtide). Mechanism of action of enfuvirtide (Fuzeon). From Wikipedia Enfuvirtide works by disrupting the HIV-1 molecular machinery at the final stage of fusion with the target cell, preventing uninfected cells from becoming infected.

Inferferons: definition and mechanism of action explained in a flash animation

What are interferons? From Wikipedia: Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, parasites and tumor cells. Interferons belong to the large class of glycoproteins known as cytokines. Interferons are produced by a wide variety of cells […]

Atazanavir (Reyataz) for HIV-1 infection: SMC review

The Scottish Medicines Consortium issued on 7th December, 2008 an advice on the recently approved protease inhibitor Atazanavir (Reyataz) Atazanavir (Reyataz) is accepted for use within NHS Scotland in antiretroviral treatment naïve HIV-1 infected adults in combination with other antiretroviral medicinal products. The combination of atazanavir and ritonavir was non-inferior to a standard boosted protease inhibitor […]