EMA: Use modafinil only for narcolepsy

The European Medicines Agency recommended restricting the use of modafinil for narcolepsy only. “The European Medicines Agency has recommended restricting the use of modafinil-containing medicines. The medicine should only be used to treat sleepiness associated with narcolepsy. Doctors and patients should no longer use the medicine for the treatment of idiopathic hypersomnia, excessive sleepiness associated with […]

The coagulation cascade

Coagulation cascade: several resources (videos, animations and tutorials) depicting coagulation factors and pathways.

Animation showing the Jak-Stat signalling pathway mechanism

The Jak-Stat pathway has recently attracted researchers’ attention. This has been motivated by the fact that this pathway is a potential target of future agents for the treatment of myeloproliferative disorders such as: polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. The animation below depicts the Jak-Stat signalling pathway mechanism: As mentioned above, there […]

Thrombolytic agents: mechanism of action, indications, contraindications and side effects

Thrombolytic agents are used to lyse already formed blood clots in clinical settings where ischemia may be fatal ( acute mycardial infarction, pulmonary embolism, ischemic stroke, and arterial thrombosis). Very precise indications rule the use of these drugs, which are not free from serious side effects ( bleeding). Outline: Mechanism of action of thrombolytic therapy […]

Collection of PowerPoint lectures on ANS pharmacology

The following set of lectures has been created by Dr. Edwin Jackson and were published in the Division for Cardiovascular Pharmacology, a branch of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Why study autonomic pharmacology? Outline of slides: Parasympathetic Ganglionic Synapse, Parasympathetic Organ Synapse, Sympathetic Ganglionic Synapse, Sympathetic Ganglionic Synapse, How do drugs […]