The following pharmacology lecture was developed by the Department of Pharmacology and Therapeutics, at American University of Beirut.
Download PPT file: Neuromuscular Blockers
An outline of the slideshow content:
- Neuromuscular blockers differ from each other in: • Mechanism of action • Duration of action • Speed of onset and offset of action • Selectivity of action and safety margin • Adverse effects
- Classification of Blockers
- Site of Action
- Non-depolarizing Block
- Comparison of Competitive and Depolarizing Blocking Agents
- Sequence of Paralysis: Fingers, orbit (small muscles) limbs neck Trunk Diaphragm, Intercostals. Recovery in Reverse
- Adverse Effects/Toxicity
- Dual Block by Depolarizing Agents
- Other Effects of Neuromuscular Blockers
- Hemodynamic Effects of d-Tubocurarine and Pancuronium CO
Non-depolarizing blocking agents
Atracurium (Tracrium), Cisatracurium (Nimbex), Doxacurium (Nuromax), Gallamine (Flaxedil), Mivacurium (Mivacron), Pancuronium (Pavulon), Pipecuronium, Rapacuronium (Raplon)
Depolarizing blocking agents
Succinylcholine, Decamethonium