Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents

Author: Gary Kaiser Biology Department The Community College of Baltimore County, Catonsville Campus Baltimore, MD 21228 USA Email: From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008): “Macrolides mechanism of action (MOA) The macrolides bind irreversibly to a site on the 50S subunit of the bacterial ribosome, thus inhibiting the translocation steps […]

Protein synthesis inhibitors: aminoglycosides mechanism of action animation. Classification of agents

The following animation depicts the mechanism of action of aminoglycosides. This antibiotic class includes drugs such as gentamicin, streptomycin (used for TB treatment), amikacin, among others. Aminoglycosides mechanism Susceptible gram-negative organisms allow aminoglycosides to diffuse through porin channels in their outer membranes. These organisms also have an oxygen-dependent system that transports the drug across the […]