Gary Kaiser
Biology Department
The Community College of Baltimore County, Catonsville Campus
Baltimore, MD 21228

From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008):

“Macrolides mechanism of action (MOA)

The macrolides bind irreversibly to a site on the 50S subunit of the bacterial ribosome, thus inhibiting the translocation steps of protein synthesis . They may also interfere at other steps, such as transpeptidation. Generally considered to be bacteriostatic, they may be bactericidal at higher doses. Their binding site is either identical or in close proximity to that for clindamycin and chloramphenicol.”

Common antibiotic macrolides:

Further reading

Gilbert, D; Moellering R (editors) “Sanford Guide to Antimicrobial Therapy”, 39th edition. Antimicrobial therapy: 2009

Hauser, A. “Antibiotic Basics for Clinicians: Choosing the Right Antibacterial Agent”.1st edition. LWW:2007

Gallagher, J. “Antibiotics Simplified”. 1st edition. Jones & Bartlett Publishers: 2008

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