Estradiol receptor signal transduction: 3-D video animations explaining its mechanism of action.

Two excelent 3D animations about the mechanism of action of estradiol in the activation of estradiol receptor.


Additional information from Wikipedia article on estrogen receptor:

“There are two types of estrogen receptor, ER is a member of the nuclear hormone family of intracellular receptors which is activated by the hormone 17β-estradiol[1] (estrogen), while the estrogen (G protein coupled) receptor GPER is a G-protein coupled receptor. This article refers to the nuclear hormone receptor ER.

The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding. “

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