This presentation is focused on the core characteristics of cephalosporins as a group. It highlights the differences in terms of bacterial coverage between different generations, using some clinical uses as examples. PowerPoint: cephalosporins pharmacology Lecture outline: Chemical characteristics of beta-lactams. Mechanism of action. First, second, third and fourth generation cephalosporins drug list. Bacterial coverage of […]
This post features two clinical guidelines on the management of community acquired pneumonia.
The British Thoracic Society updated this year many recommendations, including when to order a chest X-ray, and antibiotic management.
The guidelines issued by the Infectious Diseases Society of America and the AmericanThoracic Society have relevant recommendations concerning empirical antimicrobial therapy and its duration.
Vancomycin is a tricyclic glycopeptide that has gained clinical importance thanks to its effectiveness against organisms such as MRSA and enterococci. It has activity against Gram-positive rods and cocci, Gram-negative rods are resistant to its bactericidal action. Some clinical uses of IV vancomycin include treatment of infective endocarditis and sepsis caused by MRSA. Since vancomycin […]
Brief introduction to the general principles of the pharmacology of infections. Though oriented to a general audience, it is a very interesting and accurate presentation on antibiotics and antivirals.
The FDA updated the full prescribing information of ceftriaxone (Rocephin and generics). This is an update to a previous ( september 2007) alert on the risk of interaction between ceftriaxone and calcium-containing IV products, the 2007 alert was based on reported fatal cases in neonates.
50 multiple choice questions on pharmacology of antiretrovirals and antibiotics (tetracyclines, tuberculosis drugs and fluoroquinololones)
Chemotherapy MCQs. Pre-test practice questions on hiv drugs, penicillins, aminoglycosides, macrolides, tetracyclines, streptogramins and other pharmacological classes.
The Scottish Medicines Consortium issued an advice on the current indications for doripenem (Doribax): Doripenem (Doribax) is accepted for restricted use within NHS Scotland for the treatment of complicated intra-abdominal infections in adults. In patients with complicated intra-abdominal infection, doripenem is associated with clinical cure rates non-inferior to those of another carbapenem. Doripenem should be […]
Free download: pharmacology flash cards. Antibiotics, antivirals, antiretrovirals and antitubercular drugs
The Department of Pharmacology of the University of Utah has developed some study aids available at their website. Below is the summary of the file on antibiotics and related drugs, and the link to the original file. Antibacterial Drugs Sulfonamides: Sulfisoxazole (Gantrisin), Sulfamethoxazole (Gantanol), Sulfadiazine, Sulfasalazine (Azulfidine), Sulfacetamide sodium (Sulamyd Sodium) Trimethoprim-Sulfamethoxazole (Bactrim, Septra) Chloramphenicol […]
This video pharmacology review for nurses deals with antibiotics: penicilins, cephalosporins, aminoglycosides, vancomycin and others. Part 2 covers: macrolides, , chloramphenicol, quinolones, and sulfonamides. There is a related animation that explains linezolid mechanism. More on nursing pharmacology Further reading Gilbert, D; Moellering R (editors) “Sanford Guide to Antimicrobial Therapy”, 39th edition. Antimicrobial therapy: 2009 Hauser, […]
This animation depicts the mechanism of action of linezolid (Zyvox): Further reading Gilbert, D; Moellering R (editors) “Sanford Guide to Antimicrobial Therapy”, 39th edition. Antimicrobial therapy: 2009 Hauser, A. “Antibiotic Basics for Clinicians: Choosing the Right Antibacterial Agent”.1st edition. LWW:2007 Gallagher, J. “Antibiotics Simplified”. 1st edition. Jones & Bartlett Publishers: 2008
Information from Health Canada about retapaumulin (Altargo), a pleuromutilin antibiotic for the treatment of impetigo and skin infections. On March 19, 2008, Health Canada issued a Notice of Compliance to GlaxoSmithKline Inc. for the drug product AltargoTM. AltargoTM contains the medicinal ingredient retapamulin which is an antibiotic. AltargoTM is indicated for use in adult and […]
Author: Gary Kaiser Biology Department The Community College of Baltimore County, Catonsville Campus Baltimore, MD 21228 USA Email: firstname.lastname@example.org From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008): “Macrolides mechanism of action (MOA) The macrolides bind irreversibly to a site on the 50S subunit of the bacterial ribosome, thus inhibiting the translocation steps […]
Protein synthesis inhibitors: aminoglycosides mechanism of action animation. Classification of agents
The following animation depicts the mechanism of action of aminoglycosides. This antibiotic class includes drugs such as gentamicin, streptomycin (used for TB treatment), amikacin, among others. Aminoglycosides mechanism Susceptible gram-negative organisms allow aminoglycosides to diffuse through porin channels in their outer membranes. These organisms also have an oxygen-dependent system that transports the drug across the […]
Author Gary Kaiser Biology Department The Community College of Baltimore County, Catonsville Campus Baltimore, MD 21228 USA Email: email@example.com From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008): ” Tetracyclines The tetracyclines are a group of closely related compounds that, as the name implies, consist of four fused rings with a system of […]