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Thiazolidinediones (glitazones) may increase the risk of fracture in women
From the excellent blog “Prescribing Advice for GPs“: “The Journal of the Canadian Medical Association (CMAJ) has published the results of a systematic review and meta-analysis that aimed to quantify the fracture risk associated with glitazone therapy. There is also an accompanying editorial. This study has also reached the general media (BBC). The analysis examined data
An FDA advisory panel voted to ban formoterol (Serevent) and salmeterol (Foradil)
From JournalWatch: FDA Panel Votes to Ban Two Drugs for Asthma An advisory panel to the FDA voted Thursday to ban two long-acting beta agonists, Serevent (salmeterol) and Foradil (formoterol), for treating asthma in adults and children. When taken without an inhaled corticosteroid, these drugs can
NSAIDS risks and benefits podcast
This week Therapeutics initative podcast deals with NSAIDS: NSAIDS: Considering the Risks and Benefits (Therapeutics Initiative Podcast – December 10th) In our 33rd episode we follow-up our discussion of osteoarthritis by examining the risks and benefits of oral anti-inflammatories including Cox-2 inhibitors. We review the effects on pain relief and the theory of anti-inflammation. We
Pharmacology mnemonic. Propylthiouracil (PTU) mechanism of action.
Propylthiouracil (PTU) mode of action It inhibits PTU: Peroxidase/Peripheral deiodination Tyrosine iodination Union (coupling) Thanks to Medexcel
EMEA’s opinion to designate new orphan drugs
ORPHAN MEDICINAL PRODUCT DESIGNATION The COMP adopted six positive opinions recommending the following medicines for designation as orphan medicinal products to the European Commission: For the following medicines the EMEA review began on 12 September 2008 with an active review time of 90 days.
Pharmacology Mnemonics. Warfarin: action, monitoring, MOA
Warfarin: action, monitoring WePT: Warfarin works on the extrinsic pathway and is monitored by PT. Warfarin: metabolism SLOW : _ Has a slow onset of action. _ A quicK Vitamin K antagonist, though. Small lipid-soluble molecule Liver: site of action Oral route of administration. Warfarin Thanks to MedExcel
FDA: statins do not increase the risk of amyotrophic lateral sclerosis (ALS)
From FDA’s patient safety news website: Statin Use and the Risk of ALS A recent FDA analysis provides new evidence that using statins does not increase the risk of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease also known “Lou Gehrig’s Disease.” Cholesterol-lowering statins such as Lipitor (atorvastatin calcium) and Zocor (simvastatin) have been shown to
Pharmacology mnemonic. HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions
Pharmacology mnemonic about: HMG-CoA reductase inhibitors (statins): side effects, contraindications, interactions HMG CoA: Side effects: H epatotoxicity M yositis [aka rhabdomyolysis] _ Contraindications: G irl during pregnancy/G rowing children _ Interactions: C oumarin/ C yclosporine Also, check a related animation on their mechanism of action. Thanks to MedExcel
Pharmacology mnemonic. Beta-blockers: main contraindications and cautions
Beta-blockers: main contraindications, cautions ABCDE: Asthma Block (heart block) COPD Diabetes mellitus Electrolyte (hyperkalemia) From MedicalMnemonics.com
Pharmacology mnemonic: Beta 2 agonists
A mnemonic to remember the Beta 2 agonists agents: B2agonist……SMART 1)Salmeterol 2)Metaproterenol (Orciprenaline) 3)Albuterol 4)Ritodrine 5)Terbutaline Posted by SDK at Prep4USMLE Forum: Pharmacology Forum
Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents
Author: Gary Kaiser Biology Department The Community College of Baltimore County, Catonsville Campus Baltimore, MD 21228 USA Email: gkaiser@ccbcmd.edu From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008): “Macrolides mechanism of action (MOA) The macrolides bind irreversibly to a site on the 50S subunit of the bacterial ribosome, thus inhibiting the translocation steps
FDA video on Ephedrine and Epinephrine: how to prevent mistakes in their administration.
From FDA Patient Safety News: “Drug Name Confusion: Ephedrine and Epinephrine The Institute for Safe Medication Practices (ISMP) is warning again about the possibility of mix-ups between ephedrine and epinephrine. Not only do the names of these drugs look and sound similar, but since they’re both used as vasopressors and vasoconstrictors, they’re often stored next
Aldosterone mechanism of action video animation
From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008): ” Mineralocorticoids Mineralocorticoids help to control the body’s water volume and concentration of electrolytes, especially sodium and potassium. Aldosterone acts on kidney tubules and collecting ducts, causing a reabsorption of sodium, bicarbonate, and water.
Protein synthesis inhibitors: aminoglycosides mechanism of action animation. Classification of agents
The following animation depicts the mechanism of action of aminoglycosides. This antibiotic class includes drugs such as gentamicin, streptomycin (used for TB treatment), amikacin, among others. Aminoglycosides mechanism Susceptible gram-negative organisms allow aminoglycosides to diffuse through porin channels in their outer membranes. These organisms also have an oxygen-dependent system that transports the drug across the
Protein synthesis inhibitors: tetracyclines mechanism of action animation. Classification of agents
Author Gary Kaiser Biology Department The Community College of Baltimore County, Catonsville Campus Baltimore, MD 21228 USA Email: gkaiser@ccbcmd.edu From Richard Harvey (series editor), Lippincott’s Illustrated Reviews: Pharmacology (LWW, 2008): ” Tetracyclines The tetracyclines are a group of closely related compounds that, as the name implies, consist of four fused rings with a system of