Differences between tricyclic antidepressants and SNRIs mechanism of action
Images, mindmaps and tables integration of both TCAs and SNRIs MOA. Muscarinic, histaminic and alpha 1 receptors blockade determines TCAs
Video on aspirin pharmacokinetics: the role of the ion trapping phenomenon
Pharmacology video animation on aspirin (ASA) pharmacokinetics. It depicts how pH influences the gastric absorption of aspirin.
Serotonin (5-HT): receptors, agonists and antagonists
Serotonin receptors characteristics, classification and drugs that influence serotonergic transmission. Pharmacology review.
Collection of PowerPoint lectures on ANS pharmacology
The following set of lectures has been created by Dr. Edwin Jackson and were published in the Division for Cardiovascular Pharmacology, a branch of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Why study autonomic pharmacology? Outline of slides: Parasympathetic Ganglionic Synapse, Parasympathetic Organ Synapse, Sympathetic Ganglionic Synapse, Sympathetic Ganglionic Synapse, How do drugs […]
Pharmacokinetics in critical care: PowerPoint presentation
This presentation entitled “Applied Pharmacokinetics in the Adult Critically Ill” is oriented to show pharmacokinetics concepts that are relevant to the ICU. Some of them are: First pass metabolism Patients in whom oral administration should be avoided P-glycoprotein (P-gp) Relevance of drug distribution in compartments Context specific half life Cytochrome 450 Pharmacogenetics Pharmacotherapy in critical […]
Drugs for CINV prophylaxis and treatment
This article overviews the pharmacology of drugs used for the prevention and treatment of chemotherapy induced nausea and vomiting (CINV). A brief introduction on the pathophysiology is presented, to be followed by a discusssion on the different drug classes.
Clinical guidelines on CINV management
These are the latest guidelines on antiemetic managagement of chemotherapy-induced nausea and vomiting published on The Oncologist. Below that, an article from Supportive Oncology discusses the most relevant changes made in the 2006 update.
Hypertension management: pharmacotherapy lecture notes (PDF)
Phharmacological management of hypertension: by the Pharmacology OpenCourseWare initiative at Harvard Medical School – MIT.
PowerPoint: overview of cephalosporins pharmacology
This presentation is focused on the core characteristics of cephalosporins as a group. It highlights the differences in terms of bacterial coverage between different generations, using some clinical uses as examples. PowerPoint: cephalosporins pharmacology Lecture outline: Chemical characteristics of beta-lactams. Mechanism of action. First, second, third and fourth generation cephalosporins drug list. Bacterial coverage of […]
Animation: NRTIs mechanism of action
Nucleoside analog reverse transcriptase inhibitors (NRTIs) are nucleoside analogues that act as competitive inhibitors of HIV-1 reverse transcriptase. As shown in the animation, these drugs compete with nucleoside triphosphates for access to reverse transcriptase. All NRTIs lack a 3-hydroxyl group; thus, their incorporation into a growing DNA chain results in its termination. They require intracytoplasmic […]
Calcium channel blockers: classification, mechanism of action and indications
Overview on calcium channel blockers, in this first part we will discuss their classification, mechanism of action as well as clinical indications.
Animation: oral contraceptives mechanism of action
This animation depicts the endocrine mechanism of action of combined oral contraceptive pills by explaining its effect on the menstrual cycle.
Clinical guidelines on pneumonia management and treatment
This post features two clinical guidelines on the management of community acquired pneumonia.
The British Thoracic Society updated this year many recommendations, including when to order a chest X-ray, and antibiotic management.
The guidelines issued by the Infectious Diseases Society of America and the AmericanThoracic Society have relevant recommendations concerning empirical antimicrobial therapy and its duration.
Drug therapy for heart failure: PowerPoint presentations
Both lectures provide an introduction on clinical features of the disease and its physiopathology, later they review the most relevant pharmacological properties of each drug class.