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The largest case of scientific misconduct to date ?
Found via Pharmola: “Scott S. Reuben, MD, of Baystate Medical Center in Springfield, Mass., a pioneer in the area of multimodal analgesia, is said to have fabricated his results in at least 21, and perhaps many more, articles dating back to 1996. The confirmed articles were published in Anesthesiology, Anesthesia and Analgesia, the Journal of
Podcast commenting on JUPITER trial
Essential Evidence Plus, formerly InfoPOEMs is a service by John Wiley and Sons that aims to give physicians succinct medical evidence that will impact in their medical practice. In this podcast Dr. Ebell and Dr. Wilkes (National Public Radio) discuss the JUPITER trial: Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive
Updated SIGN clinical guideline: Pain management in adults with cancer
The Scottish Intercollegiate Guidelines Network (SIGN) updated a clinical guideline entitled “Control of pain in adults with cancer”. An outline of the contents (drug therapy related) in this guideline for the treatment of cancer induced pain include: Principles of pain management: introduction, World Health Organization cancer pain relief programme, using the WHO ladder. Treatment with
PowerPoint presentations on pharmacogenomics and personalized medicine
What is Pharmacogenomics? Dr. Aquilante, Professor in Pharmaceutical Sciences explains in a PowerPoint presentation its differences with pharmacogenetics and the future of personalized medicine.
Experts comment the JUPITER trial in the latest NEJM issue
Experts around the globe comment the JUPITER trial in the correspondence section of the March 5, 2009 issue of the NEJM. I collect here some of the most relevant and interesting correspondence to the editor. “JUPITER is notable for the unacknowledged exclusion of a population that may be at increased risk for dose-related adverse effects
Atomoxetine (Strattera) for ADHD: risk of psychotic or manic symptoms
The Medicines and Healthcare products Regulatory Agency (MHRA) has published Drug Safety Update for March 2009. One of the drugs reviewed is atomoxetin (Strattera), a norepinephrine reuptake inhibitor used for the treatment of ADHD. These are the recommendations: Advice for healthcare professionals: • At normal doses, atomoxetine can be associated with treatment-emergent psychotic or manic
PowerPoint presentation: drugs for the treatment of angina pectoris (nitrates, beta blockers)
The following set of pharmacology lectures has been created by Dr. Garret Gross and were published in the Division for Cardiovascular Pharmacology, a branch of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Antianginal drugs lecture Outline: Myocardial Preconditioning, Nitrates tolerance (how to avoid it),contraindications. ß-adrenergic blockers contraindications. Reasons for Using Nitrates and Beta
MCQs for USMLE review on psychopharmacology: antipsychotics, benzodiazepines, antidepressants and lithium
These pharmacology MCQs from the UMKC School of Medicine have a different degree of difficulty, but are useful to review pharmacology of psychotropics. Psychotropics Item Number: 11667 correct answer: 4 category: Psychotropics 1. The symptoms of tardive dyskinesia will acutely improve with: 1. administration of diphenhydramine 2. administration of amantadine 3. administration of bromocriptine 4.
SMC recommendations for doripenem : second or third line treatment of intra-abdominal infections
The Scottish Medicines Consortium issued an advice on the current indications for doripenem (Doribax): Doripenem (Doribax) is accepted for restricted use within NHS Scotland for the treatment of complicated intra-abdominal infections in adults. In patients with complicated intra-abdominal infection, doripenem is associated with clinical cure rates non-inferior to those of another carbapenem. Doripenem should be
Study aid for antiviral agents: table summarizing their spectrum of activity
The following images created by the Dept. of Pharmacology at University of Utah are great for reviewing antifungals before a test like USMLE: This table contains the following agents: Trifluridine, Vidarabine, acyclovir, ganciclovir, foscarnet, azt, ddI, ribavirin, amantadine.
Video: agonist and antagonist concepts explained with simple examples
This video was developed by nursing students to explain in plain English the concepts of agonist, antagonist and intrinsic activity. The make use of simple analogies to make clear pharmacodynamics topics.
Antidepressants podcast: comments on the latest ACP clinical guidelines
Essential Evidence Plus, formerly InfoPOEMs is a service by John Wiley and Sons that aims to give physicians succinct medical evidence that will impact in their medical practice. In this podcast Dr. Ebell and Dr. Wilkes (National Public Radio) discuss the POEM that analyzes the ACP guidelines (published in Annals of Internal Medicine) on antidepressants.
PowerPoint presentation: “Marketing Practices of the Pharmaceutical Industry”
Southern Collaboration in Research to Impact Prescription of Therapeutics (SCRIPTS) is a project aimed to"help prescribers enhance their ability to evaluate drug related information to improve their prescribing practices and describe proper prescribing practices to improve quality of patient care". It is sponsored by University of Alabama at Birmingham. They developed a very interesting and
Metoclopramide and tardive dyskinesia: FDA adds boxed warning
The FDA issued a press release (dated February 26, 2009) in which they announce that the agency will require Metoclopramide (Maxolon, Reglan, Degan, Maxeran, Primperan, and Pylomid) manufacturers to include a boxed warning about the risk of long term or high dose use: The U.S. Food and Drug Administration announced today that manufacturers of metoclopramide,
Study aids for antifungals pharmacology: diagram showing MOA and table summary for activity spectrum
The following images created by the Dept. of Pharmacology at University of Utah are great for reviewing antifungals before a test like USMLE: Diagram of sites of action of major antifungals Table: Spectrum of activity of antifungal agents Agents: Amphotericin, nystatin, flucytosine, azoles: miconazole, ketoconazole, itraconazole, fluconazole, griseofulvin Technorati : Antifungals, mechanism of action, tables