NClEX video review: antifungals pharmacology

Some of the drugs covered are: Amphotericin B, Ketoconazole (Nizoral), griseofulvin, terbinafine “Azole” antifungals: Fluconazole (Diflucan), Itraconazole, Vorconazole, Nystatin, Mycostatin

Study aids for antifungals pharmacology: diagram showing MOA and table summary for activity spectrum

The following images created by the Dept. of Pharmacology at University of Utah are great for reviewing antifungals before a test like USMLE: Diagram of sites of action of major antifungals Table: Spectrum of activity of antifungal agents Agents: Amphotericin, nystatin, flucytosine, azoles: miconazole, ketoconazole, itraconazole, fluconazole, griseofulvin Technorati : Antifungals, mechanism of action, tables

PowerPoint presentation: ACE inhibitors, ARBs, and calcium channel blockers

The following pharmacology PowerPoint has been developed by Ed Sheridan, Pharm.D. Outline: ACE inhibitors, Angiotensin II Receptor Blockers (ARBs), and calcium channel blockers •Review the Mechanism of Action •Review Safety •Review Efficacy •Hypertension Download ppt slides: pharmacology of ACEi, ARBs, and Calcium channel blockers. You may also find interesting related PowerPoint presentation on drug therapy […]

Vorinostat MSD for cutaneous T-cell lymphoma. MSD withdraws marketing application

Excerpts from the EMEA press release (dated 17th February) on the withdrawal of the marketing application for Vorinostat MSD: The European Medicines Agency (EMEA) has been formally notified by Merck Sharp & Dohme Ltd of its decision to withdraw its application for a centralised marketing authorisation for the medicine Vorinostat MSD (vorinostat), 100 mg hard […]

Animation on histamine release and antihistamines mechanism of action

In this 3-D animation, oriented to the general public, we can see the process of histamine release by mast cell starting from the exposure to the allergen: This image shows the same process: H1 blockers are a class of widely prescribed drugs, here an excerpt of its pharmacodynamics (Source: Katzung’s Basic and Clinical Pharmacology) A. […]

P-glycoprotein: animation showing its role in chemotherapy resistance

Some introductory information about MDR1, the protein that mediates resistance to chemotherapeutic agents, from Wikipedia: P-glycoprotein (plasma gycoprotein, abbreviated as P-gp or Pgp) is a well-characterized ABC-transporter of the MDR/TAP subfamily. P-gp is also called ABCB1, ATP-binding cassette sub-family B member 1, MDR1, and PGY1. P-glycoprotein has also recently been designated CD243 (cluster of differentiation 243). […]

Video animation: mechanism of ionotropic receptors or ligand-gated ion channels (LGICs)

In pharmacology, receptors can be divided into 4 general groups: 1. Ion channels: Ligand gatedace Voltage gated Second messenger regulated 2. G protein coupled receptors 3. Receptor tyrosine kinase 4. Intracellular hormone receptors: like  the glucocorticoid receptor The video animation below shows the activation of a ionotropic receptor or ligand-gated ion channel (LGIC): An excerpt […]

Linezolid (an oxazolidinone): mechanism of action animation

This animation depicts the mechanism of action of linezolid (Zyvox): Further reading Gilbert, D; Moellering R (editors) “Sanford Guide to Antimicrobial Therapy”, 39th edition. Antimicrobial therapy: 2009 Hauser, A. “Antibiotic Basics for Clinicians: Choosing the Right Antibacterial Agent”.1st edition. LWW:2007 Gallagher, J. “Antibiotics Simplified”. 1st edition. Jones & Bartlett Publishers: 2008

Mechanism of action video animation: ACE inhibitors, Angiotensin II receptor blockers (ARBs) and the Renin Angiotensin Aldosterone System

Also, a diagram of the Renin Angiotensin Aldosterone System (RAAS System) physiology. Drugs acting on the Renin Angiotensin Aldosterone System. ACE Inhibitors. List of agents Sulfhydryl-containing agents Captopril (Capoten), Zofenopril Dicarboxylate-containing agents Enalapril (Vasotec, Renitec) Ramipril (Altace, Tritace, Ramace, Ramiwin) Quinapril (Accupril) Perindopril (Coversyl, Aceon) Lisinopril (Lisodur, Lopril, Novatec, Prinivil, Zestril) Benazepril (Lotensin) Phosphonate-containing agents […]

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