The following video is a short overview on the pharmacological basis of SSRIs side effects. Outline: Facts about SSRIs adverse effects. Gastrointestinal adverse effects. 5-HT3 and 5-HT4 receptors in the GI tract. 5-HT3 receptors in the brainstem and hypothalamus. CNS adverse effects. 5-HT2A receptor stimulation at the basal ganglia. 5-HT2A and 2C receptors are hypothetically…
Category Archives: CNS drugs
Glutamate receptors
Overview of ionotropic (NMDA, AMPA, Kainate) and metabotropic glutamate receptors (mGluR).
Differences between tricyclic antidepressants and SNRIs mechanism of action
Images, mindmaps and tables integration of both TCAs and SNRIs MOA. Muscarinic, histaminic and alpha 1 receptors blockade determines TCAs
Serotonin (5-HT): receptors, agonists and antagonists
Serotonin receptors characteristics, classification and drugs that influence serotonergic transmission. Pharmacology review.
Drugs for CINV prophylaxis and treatment
This article overviews the pharmacology of drugs used for the prevention and treatment of chemotherapy induced nausea and vomiting (CINV). A brief introduction on the pathophysiology is presented, to be followed by a discusssion on the different drug classes.
Clinical guidelines on CINV management
These are the latest guidelines on antiemetic managagement of chemotherapy-induced nausea and vomiting published on The Oncologist. Below that, an article from Supportive Oncology discusses the most relevant changes made in the 2006 update.
How to survive your first night on call: PowerPoint presentation
This PowerPoint presentation has great suggestions and tips on how to handle a night on call. It is specially useful for junior physicians and covers real-life clinical situations you may encounter.
Pregabalin (Lyrica) not approved for fibromyalgia by the EMEA
EMEA didn’t approve treatment of fibromyalgia as a new indication for pregabalin (Lyrica).The CHMP was concerned that the benefits of Lyrica in fibromyalgia had not been shown in either the short or the long term.
Aripiprazole (Abilify) not approved for bipolar disorder
According to a press release, the Scottish Medicines Consortium (SMC) did not accept aripiprazole for the treatment of manic episodes in bipolar I disorder and for the prevention of new manic episodes. According to the SMC, the manufacturer did not present a sufficiently robust economic analysis to gain acceptance. Psychiatrist Daniel Carlat from “The Carlat…
Agomelatine (Valdoxan) for major depressive episodes
Agomelatine (Valdoxan, Melitor, Thymanax) is a recently marketed new drug for the treatment of major depression with a novel mechanism of action. It can be included in the class of “other antidepressants”, or classified as a melatonergic drug. Mechanism of action Agomelatine acts as an agonist on melatonin MT1 and MT2 receptors. Additionally, it blocks…
FDA video warning on metoclopramide and tardive dyskinesia
Video: patient safety warning on chronic use of metoclopramide and the risk of developing tardive dyskinesia.
Lectures on antiemetics pharmacology: MOA, indications, side effects and new drugs reviewed
PowerPoint slideshows on pharmacology of antiemetics .MOA, dosing, indications and side effects of: serotonin and dopamine antagonists, anticholinergics, new antiemetics.
PowerPoint slideshow lectures: overview on antidepressants pharmacology
PowerPoint lectures on antidepressants pharmacology. MOA, pharmacokinetics, indications, and side effects of: tryciclics, SSRIs, heterocyclics, MAO inhibitors.
